Topic · Geriatrics and Gerontology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
11 papers
Thomas E. Akie, Ethan B Loew, Ziyuan Huang, Haley A. Neff, Olivia P Michaels, John Patrick Haran
This study identifies T lymphocyte regulatory cytokines as predictors of frailty in older adults using machine learning and serum cytokine analysis.
BMC Geriatrics · Oct 28, 2026Peer-reviewedImmunology
Kun Zhao, Candice Quin, Yash Pershad, Liying Xue, Weizhi Cao, Grace I. Bowman, Caitlyn Vlasschaert, Robert W. Corty, Jonathan Brett Heimlich, Erica N. DeJong, Caitlin Lee, Zil Patel, Marco M. Buttigieg, Chris P. Verschoor, Calum A Bane, , Alexander G. Bick
This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.
medRxiv · Oct 1, 2026 · PreprintGenetic & Genomic Medicine
Matías Fuentealba, Ting Zhai, Saleem Al Dajani, Vadim N. Gladyshev, Michael P. Snyder, David Furman
This study uses UK Biobank data to develop an 18-year mortality risk estimator for domain-specific intrinsic capacity, identifying immune system activation across domains.
bioRxiv · Apr 8, 2026 · PreprintSystems Biology
Xianping Hu, Wei Zheng, Yiyuan Li, Daixing Zhou
This study identifies molecular signatures for frailty using transcriptomic data from two datasets, highlighting vitamin D metabolism and inflammatory pathways as key features.
bioRxiv · Mar 20, 2026 · PreprintBioinformatics
Chanhong Min, Charles Ezenwanne, Yoseph W. Dance, Nicolas C. Macaluso, Ladaisha T. Thompson, Lolita S. Nidadavolu, Akhil Katuri, Crystal Szczesny, Jacqueline M. Langdon, Edward J. Pearce, Peter M. Abadir, Jeremy D Walston, Jude M. Phillip
This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.
bioRxiv · Mar 12, 2026 · PreprintBioengineering
Dantong Zhu, Judy Z. Wu, Patrick T. Griffin, Brady A. Samuelson, David A. Sinclair, Alice E. Kane
This study identifies sex-specific metabolite biomarkers of frailty in aging mice using longitudinal metabolomics and machine learning.
npj Aging · May 23, 2025Peer-reviewedBiochemistry
Jonny P Flint, Miles Welstead, Simon R. Cox, Tom C. Russ, Alan D. Marshall, Michelle Luciano A
This paper uses multi-polygenic scores to predict frailty and its trajectories, identifying chronic pain, rheumatoid arthritis, and educational attainment as key pathways.
medRxiv · May 31, 2024 · PreprintGenetic & Genomic Medicine
Jonny P Flint, Miles Welstead, Simon R. Cox, Tom C. Russ, Alan D. Marshall, Michelle Luciano A
This study validates a polygenic risk score for frailty using two independent cohorts, showing it predicts frailty at early ages with moderate variance explained.
medRxiv · Apr 3, 2023 · PreprintGenetic & Genomic Medicine
Janice L. Atkins, Juulia Jylhävä, Nancy L. Pedersen, Patrik K. E. Magnusson, Yi Lu, Yunzhang Wang, Sara Hägg, David R. Melzer, Dylan M. Williams, Luke C. Pilling
This study performs a genome-wide association study of frailty index to identify genetic signals and pathways, finding synapse function enrichment and associations with educational attainment.
Aging Cell · Aug 25, 2021Peer-reviewedGenetic & Genomic Medicine
Ahmed Ghachem, Linda P. Fried, Véronique Legault, Karen Bandeen‐Roche, Nancy Presse, Pierrette Gaudreau, Alan Arthur Cohen
This study investigates frailty as an emergent property of physiological system dysregulation using Mahalanobis distance in two older adult cohorts, finding partial support for breadth and nonlinearity of associations.
Biogerontology · Oct 16, 2020Peer-reviewedSystems Biology
Timothy V. Pyrkov, Evgeny Getmantsev, Boris Zhurov, Konstantin Avchaciov, Mikhail A. Pyatnitskiy, L. I. Men’shikov, Kristina Khodova, Andrei V. Gudkov, Peter O. Fedichev
The paper quantifies biological age and frailty using locomotor activity data from NHANES and UKB, linking aging trajectories to mortality and health outcomes.
Aging · Oct 25, 2018Peer-reviewedSystems Biology