Patrik K. E. Magnusson

Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

The paper integrates GWAS meta-analysis with human brain cell mapping to identify genetic loci and cell types involved in tinnitus, implicating the amygdala and midbrain.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

Genetic structure of major depression symptoms across clinical and community cohorts

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population

This paper conducts a GWAS of subclinical obsessive-compulsive symptoms (OCS) in 33,943 individuals, finding polygenic risk and genetic overlap with OCD.

Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits

This study identifies 20 genome-wide significant loci associated with serum IgA levels and finds genetic correlations with various immune and metabolic traits.

A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Aging

This study performs a genome-wide association study of frailty index to identify genetic signals and pathways, finding synapse function enrichment and associations with educational attainment.

Resource Profile and User Guide of the Polygenic Index Repository

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

Within-sibship GWAS improve estimates of direct genetic effects

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

Association Tests Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis

CONCUR improves power in rare CNV analysis by comparing copy number profiles without requiring locus definitions.

Genetic variation in the Major Histocompatibility Complex and association with depression

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

This study conducts a large GWAS on heart failure, identifying 12 genetic loci with associations to CAD, atrial fibrillation, and reduced left ventricular function, and provides causal evidence for several risk factors.

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

Copy number variation and neurodevelopmental problems in females and males in the general population

This study investigates the association between rare copy number variants (CNVs) and neurodevelopmental problems (NPs) in children, finding sex-specific effects in anxiety/depression.

Polygenic Link Between Blood Lipids And Amyotrophic Lateral Sclerosis

This study identifies a polygenic link between blood lipids and amyotrophic lateral sclerosis, finding causal effects of LDL-C and TC on ALS risk.

MTAG: Multi-Trait Analysis of GWAS

MTAG improves GWAS results by combining summary statistics across traits, increasing significant loci and enhancing polygenic score variance.

Equivalence of LD-Score Regression and Individual-Level-Data Methods

This paper shows that LDSC regression and individual-level data methods yield similar results under population stratification, but warns that LDSC intercepts can misattribute stratification to heritability estimates.

SweGen: A whole-genome map of genetic variability in a cross-section of the Swedish population

SweGen provides a high-quality whole-genome map of genetic variation in the Swedish population, useful for clinical genetics and association studies.

Large-scale non-targeted metabolomic profiling in three human population-based studies

The paper develops a workflow for large-scale non-targeted metabolomic profiling in human studies, detecting over 8,000 metabolic features and identifying 90 metabolites associated with hsCRP.