Connexins and lens biology

The paper solves the structure of Connexin26 from Lepidosiren paradoxa at high CO2 levels, revealing an open conformation stabilized by detergent binding between TM3 and TM4.

This study shows that mitotic nanotubes, influenced by Cx43 trafficking and actin remodeling, enable reduced gap junction communication during cell division.

This study shows that connexins Cx26 and Cx43 are critical for ependymal cell response to spinal cord injury, with Cx26 affecting proliferation and healing, and Cx43 mediating calcium signaling.

This study identifies molecular determinants of weak PDZ1/Cx36 interactions, showing that specific residues and phosphorylation regulate electrical synapse stability.

This study examines the spatial expression and cellular organisation of innexin gap junction proteins in Drosophila wing imaginal discs, revealing their sub-apical localization and functional roles.

This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.

The paper identifies a novel type of electrical synapse in C. elegans and zebrafish, called heterochannel synapses, formed by multiple innexin proteins and regulated by specific kinesins.

This study uses 2-photon fluorescence microscopy to examine lens suture structures in wildtype and KLPH-KO mice, revealing altered suture patterns and pathological features in the knockout model.

The paper shows astrocyte gap junction networks selectively connect specific brain regions and reorganize after sensory deprivation in mice.

This study uses a 3D endothelium-on-a-chip model to show that Cx43-dependent glycolytic shifts contribute to endothelial barrier dysfunction in diabetic kidney disease.

The paper shows that CO2 produced in axons gates Cx32 hemichannels in Schwann cells, mediating neuron-to-glia signaling and affecting myelin conduction.

This study shows that Cx26 deficiency in the cochlea leads to increased Cx46 expression, which compensates by forming gap junctions in the same locations as Cx26.

This paper introduces opto-δL, a method to identify and quantify electrical synapses, and applies it to map coupled networks in thalamic and cortical tissues.

This study establishes a mouse model of Crybb3 loss-of-function and identifies proteomic changes in the lens, including downregulation of multiple proteins and altered transcription factor activation.

This study shows dopamine modulates AII amacrine cell membrane potential and glycine release through D1-like receptor regulation of gap junction coupling with ON cone bipolar cells.

This study shows that 4-PBA treatment reduces MHV-A59 infectivity and demyelination by preserving Cx43 and ERp29 expression in a murine model of MS.

This study identifies GJB3 as a key gene in adenocarcinomas with low SLC7A11, showing it supports cell growth through cystine uptake and stress pathway regulation.

The paper identifies hundreds of Connexin-associated proteins in zebrafish electrical synapses, revealing molecular diversity and overlap with chemical synapse proteomes, and links these proteins to neurological disorders.

The paper identifies CFI-1/ARID3's role in regulating gap junction formation between specific neurons in C. elegans, showing unilateral control over connectivity.

The paper identifies gjd4/Cx46.8 as a gap junction protein essential for bioelectric signaling in zebrafish slow muscle development and function, showing its role in coordinating neural and muscular activity.

This study shows that electrical coupling between parvalbumin basket cells decreases after experimental status epilepticus in rats, without affecting coupling coefficient.

The paper shows that electrical synapses in C. elegans filter sensory information to guide context-specific behavioral choices by modulating neuronal excitability and integration of temperature stimuli.

The paper simulates gap junction formation and finds that cysteine residues are critical for connexon coupling and stabilization of gap junction structures.

The paper shows that gap junctions and amino acid import in somatic cells support germ cell growth in Drosophila by enabling metabolic transfer and regulating translation.

The paper shows that D-type K+ current differences between rat and mouse MesV neurons affect electrical coupling efficiency and network function.

This study identifies TMEM43 as a pH-sensing cation channel that modulates gap junction networks in the hippocampus, preventing neuronal hyperexcitability and supporting memory retrieval.

The paper shows that different isoforms of the ZO1b gene contribute uniquely to the electrical synapse density complex, affecting gap junction channel localization and function in zebrafish.

The paper identifies a mutation in tjp1b that disrupts electrical synapse formation in zebrafish by preventing neural gap junction channel localization.

The paper develops a dual voltage clamp technique to measure single channel conductance of pannexin-1 hemichannels in astrocytes and finds changes in activity in response to FGF-1 treatment.

The paper develops engineered gap junction hemichannels to enable precise, long-term neural circuit editing in mammals by enabling communication between distinct cell types.