Neuroendocrine regulation and behavior

Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles

This study shows that cesarean delivery in prairie voles leads to long-term social and physiological changes, including impaired partner preference formation, which can be reversed with oxytocin treatment.

Neuroanatomical and Functional Consequences of Oxytocin Treatment at Birth

This study examines the neurodevelopmental effects of maternal oxytocin treatment at birth on adult prairie vole offspring using MRI and functional connectivity analysis.

Altered PVN-to-CA2 hippocampal oxytocin pathway and reduced number of oxytocin-receptor expressing astrocytes in heart failure rats

The paper investigates changes in the PVN-to-CA2 oxytocin pathway in heart failure rats, finding altered oxytocinergic innervation and reduced OTR-expressing astrocytes.

Modelling sexual violence in male rats: The sexual aggression test (SxAT)

This paper introduces a novel animal model, the sexual aggression test (SxAT), to study sexual aggression in male rats and identifies neural correlates of the behavior.

Examining the effect of chronic intranasal oxytocin administration on the neuroanatomy and behavior of three autism-related mouse models

This study examines chronic intranasal oxytocin's effects on neuroanatomy and behavior in three autism-related mouse models, finding limited effects and no consistent response patterns.

IMPACT OF ADOLESCENT INTERMITTENT ETHANOL EXPOSURE IN MALE AND FEMALE RATS ON SOCIAL DRINKING AND NEUROPEPTIDE GENE EXPRESSION

This study examines how adolescent intermittent ethanol exposure affects social drinking and neuropeptide gene expression in male and female rats, revealing sex-specific impacts on ethanol consumption and hypothalamic gene expression.

Oxytocin neurons mediates the effect of social isolation via the VTA circuits

This study shows that social isolation during adolescence in mice affects social behavior and neural activity, with effects mediated by oxytocin neurons in the hypothalamus.

Plasticity of Neural Connections Underlying Oxytocin-mediated Parental Behaviors of Male Mice

The paper identifies oxytocin neurons as key regulators of paternal caregiving in male mice and shows enhanced excitatory connections from lateral hypothalamus neurons in fathers.

Aggressive but not reproductive boldness in male green anole lizards correlates with baseline vasopressin activity

The paper investigates the relationship between baseline vasopressin activity and boldness in male green anole lizards, finding an inverse correlation with aggressive but not reproductive behaviors.

Corticotropin-releasing hormone signaling from prefrontal cortex to lateral septum supports social novelty preference

The paper identifies CRH-expressing inhibitory neurons in the prefrontal cortex that project to the lateral septum, showing their role in suppressing interactions with familiar mice and supporting social novelty preference.

Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).

This study shows that oxytocin receptors influence the development and maintenance of social behavior in zebrafish, with effects varying by age and social context.

Oxytocin modulates neurocomputational mechanisms underlying prosocial reinforcement learning

This study shows that oxytocin modulates prediction error encoding in the midbrain-sgACC pathway during prosocial learning, without affecting self-oriented learning.

What are oxytocin assays measuring? Epitope mapping, metabolites, and comparisons of wildtype & knockout mouse urine

The paper investigates interference in urinary oxytocin immunoassays using knockout and wildtype mice, finding that common extraction methods fail to eliminate false positives and proposing a new extraction method to reduce interference.

Dynamic Sex Differences in Reactive and Appetitive Aggression

The paper investigates sex differences in reactive and appetitive aggression in mice using behavioral tests, revealing distinct patterns between males and females.

Urocortin-3 neurons in the perifornical area mediate the impact of chronic stress on female infant-directed behavior

The paper shows that chronic stress increases activity in PeFAUcn3 neurons in female mice, which mediates stress-induced deficits in infant-directed behavior.

Less is more: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

This study shows that lower doses of intranasal oxytocin have maximal effects on amygdala physiology, with subregion-specific responses and no disruption of cerebrovascular reactivity.

Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles

This study shows that social experience alters oxytocinergic signaling in the nucleus accumbens of female prairie voles, affecting synaptic transmission and social behavior.

Brainwide input-output architecture of paraventricular oxytocin and vasopressin neurons

The paper maps synaptic inputs and outputs of paraventricular oxytocin and vasopressin neurons in mice, revealing sex-conserved inputs and sex-differentiated outputs.

Anxiolytic effects of chronic intranasal oxytocin on neural responses to threat are dose-frequency dependent

This study investigates the anxiolytic effects of chronic intranasal oxytocin, finding that low-frequency dosing reduces neural threat reactivity in high-anxiety individuals.

Adolescent rats extend help to outgroup members, highlighting a neural network for group identity categorization.

The paper shows that adolescent rats help both ingroup and outgroup members, while adults show ingroup bias, with neural activity differences in brain regions like the hippocampus and orbitofrontal cortex.

Exogenous estradiol and oxytocin modulate sex differences in hippocampal reactivity and episodic memory

This study shows that estradiol and oxytocin reduce sex differences in episodic memory and hippocampal reactivity in humans, with combined treatment restoring the sex difference.

Social selectivity and social motivation in voles

The paper examines social selectivity and motivation in voles, showing sex differences in social behavior and linking oxytocin receptor signaling to prosocial and aggressive behaviors.

Oxytocin reduces interoceptive influences on empathy-for-pain in the anterior insula

This study investigates how oxytocin affects empathy-for-pain by modulating interoceptive signals, showing that OT reduces brain reactivity to pain-related stimuli during systole.

Regional Differences in Brain Plasticity and Behaviour as a Function of Sex and Enrichment Type: Oxytocin Matters

This study examines how physical and social enrichment affect brain plasticity and behavior in male and female rats, showing sex-specific effects mediated by oxytocin.

Loneliness and the social brain: how perceived social isolation impairs human interactions

This study investigates how perceived social isolation impairs trust and social interactions by analyzing neural and behavioral responses in lonely individuals.

A reduction in voluntary physical activity during pregnancy in mice is mediated by prolactin

This study shows that prolactin suppresses voluntary physical activity in pregnant mice, with specific effects observed when prolactin receptors are deleted from certain brain regions.

Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

This study investigates the effects of intranasal vasopressin on social attention and finds it increases bottom-up processing while reducing top-down control, similar to oxytocin but with greater impact on pro-saccade errors.

Brain Areas Affected by Intranasal Oxytocin Show Higher Oxytocin Receptor Expression

The paper examines oxytocin receptor expression in brain regions affected by intranasal oxytocin and finds higher OXTR expression in affected subcortical regions.

Developmental effects of oxytocin neurons on social affiliation and processing of social information

This study shows that perturbing oxytocin neurons during zebrafish development leads to altered social behavior and neural connectivity in adulthood.

Immunoelectron microscopic characterization of vasopressin neurons in macaques by use of formaldehyde-fixed tissues stored for several years

This paper demonstrates that formaldehyde-fixed macaque brain tissues stored for years retain sufficient ultrastructural and immunoreactivity features for immunoelectron microscopic analysis of AVP neurons.