Brain Metastases and Treatment

Estradiol Reprograms Microglia to Create an Immune-Suppressed Niche Permissive to Breast Cancer Brain Metastasis

This study shows estradiol suppresses microglial immunity and promotes breast cancer brain metastasis, with E2 suppression enhancing anti-tumor responses and synergizing with radiotherapy.

Targeting wild type NTRK decreases brain metastases of lung cancers non-driven by NTRK fusions

This study shows that NTRK inhibitors can reduce brain metastases in lung cancers with wild-type NTRK, even without NTRK fusions.

RET Receptor Tyrosine Kinase Promotes Breast Cancer Metastasis to the Brain and RET Inhibitors Pralsetinib and Selpercatinib Suppress Breast Cancer Brain Metastases

This study shows RET is highly activated in breast cancer brain metastases and that RET inhibitors reduce metastasis and tumor growth in preclinical models.

Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts

This study shows FGFR1 amplification drives ER+ breast cancer brain metastasis in young and aged mice via FGF2 and NCAM1 interactions, with FGFR inhibitors effective in early stages.

Spatial profiling of central nervous system cellular markers in murine breast cancer to brain metastases

The paper uses spatial profiling to analyze cellular marker changes in murine brain metastases, identifying upregulated immune markers and downregulated neuronal markers.

Identification and characterization of tertiary lymphoid structures in brain metastases

The paper identifies tertiary lymphoid structures in brain metastases from different cancer types and links their presence to patient survival.

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach

The paper develops computational models to explain the differential growth dynamics between radiation necrosis and recurrent brain metastases, using mathematical simulations and clinical data.

Recurrently Mutated Genes Differ between Leptomeningeal and Solid Lung Cancer Brain Metastases

This study compares mutation frequencies between leptomeningeal and solid lung cancer brain metastases, finding higher EGFR mutations in leptomeningeal disease and no KRAS mutations.