Autoimmune Neurological Disorders and Treatments

NMDA-receptor-Fc-fusion constructs neutralize anti- NMDA receptor antibodies

This study develops NMDA-receptor-Fc-fusion constructs that neutralize anti-NMDA receptor antibodies and inhibit their effects on neurons.

Anti-NMDAR encephalitis antibodies cause long-lasting degradation of the hippocampal neural representation of memory

This study shows that anti-NMDAR encephalitis antibodies cause long-term hippocampal neuronal activity changes that persist after antibody clearance, leading to memory dysfunction.

Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1

The paper uses patient-derived autoantibodies to study LGI1 localization and interactome in mouse brains, revealing its synaptic distribution and novel protein complexes.

Impaired functional connectivity of the hippocampus in murine models of NMDA-receptor antibody associated pathology

This study investigates functional connectivity changes in murine models of NMDAR antibody-associated pathology using rs-fMRI, finding impaired connectivity in hippocampal regions similar to human patients.

An epitope specific patient-derived LGI1-autoantibody enhances neuronal excitability by modulating the Kv1.1 channel.

This study shows that an epitope-specific LGI1-autoantibody modulates Kv1.1 channel function, increasing neuronal excitability and potentially contributing to epileptiform activity.

Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.

Chronic Presence of Blood Circulating Anti-NMDAR1 Autoantibodies Impairs Cognitive Function in Mice

This study shows that chronic low-titer blood circulating anti-NMDAR1 autoantibodies impair spatial working memory in mice, suggesting potential cognitive effects in humans.

Investigation of anti-IgLON5-induced neurodegenerative changes in human neurons

This study shows that anti-IgLON5 antibodies cause functional and neurodegenerative changes in human neurons, leading to cell death, supporting their role in the disease.

Anti-NMDA receptor encephalitis in mice induced by active immunization with conformationally-stabilized holoreceptors

This study develops an active immunization model in mice that mimics anti-NMDA receptor encephalitis, revealing neuroinflammation and immune cell involvement in disease pathogenesis.

NMDA-receptor antibodies alter cortical microcircuit dynamics

This study shows NMDA-receptor antibodies alter cortical microcircuit dynamics and predispose to paroxysmal EEG abnormalities in a mouse model.