Nicotinic Acetylcholine Receptors Study

Post-synaptic morphology of mouse neuromuscular junctions is linked to muscle fibre type

This study quantifies post-synaptic NMJ morphology in different mouse muscles and finds it correlates with fibre type, not diameter, and shows NMJ growth rates vary across muscles.

Structural correlates of human muscle nicotinic acetylcholine receptor subunit assembly mediated by δ(+) interface residues

The paper identifies structural residues in the δ subunit of human muscle nicotinic acetylcholine receptors that influence subunit assembly and functional dynamics.

Lynx1 modulates the activity of nAChRs to slow NMJ and muscle fiber degeneration during aging

The paper withdraws its manuscript due to issues with data, interpretations, and conclusions.

Enhancement of alcohol aversion by the nicotinic acetylcholine receptor drug sazetidine-A

This study shows that sazetidine-A, a nAChR agonist, enhances alcohol aversion in mice by acting on non-4 nAChRs, reducing binge drinking without affecting nicotine consumption.

Phasic Dopamine Release Magnitude Tracks Individual Differences in Sensitization of Locomotor Response following a History of Nicotine Exposure

This study examines how repeated nicotine exposure affects dopamine release in the nucleus accumbens of rats and links these changes to locomotor sensitization and vulnerability to substance use disorder.

Double Dissociation of Nicotinic alpha-7 and alpha-4/beta-2 Sub-receptor Agonists for Enhancing Learning and Attentional Filtering of Distraction

The paper investigates the distinct roles of alpha-7 and alpha-4/beta-2 nicotinic acetylcholine receptor agonists in learning and attentional filtering using nonhuman primates, finding a double dissociation in their effects.

Distinct evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors

The paper compares evolutionary trajectories of neuronal and hair cell nicotinic acetylcholine receptors across tetrapods, finding distinct patterns in sequence conservation, co-expression, and functional properties.

Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development

The paper identifies nAchR1 and nAchR6 as key nicotinic acetylcholine receptor subunits in Drosophila LNvs and shows their transcriptional regulation is linked to synapse maturation.

A functionally conserved mechanism of modulation via a vestibule site in pentameric ligand-gated ion channels

The paper identifies a conserved vestibule binding site in pLGICs and shows nanobodies can act as allosteric modulators, expanding drug design possibilities.

Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo

This study examines the effects of alpha7 nAChR agonists and PAMs on neuronal firing activity and NMDA-evoked responses in rat CA1 hippocampal pyramidal cells in vivo.

Crosstalk with the GAR-3 receptor contributes to feeding defects in Caenorhabditis elegans eat-2 mutants

The paper investigates how ACh signaling defects in eat-2 mutants affect peristalsis and finds that crosstalk with GAR-3 receptors contributes to feeding defects and lifespan changes.

Somatic nicotinic acetylcholine receptors control the activity of dopamine neurons and reward-related behaviors.

This study shows that somatic nicotinic acetylcholine receptors in VTA dopamine neurons modulate firing properties and reward-related behaviors through optical manipulation.

Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission

This study shows that VTA glutamate neurons express nicotinic acetylcholine receptors and are modulated by cholinergic input, affecting excitatory transmission.

Nicotinic modulation of hierarchal inhibitory control over prefrontal cortex resting state dynamics: modeling of genetic modification and schizophrenia-related pathology

The paper models how genetic modifications and nicotine affect neural activity states in the prefrontal cortex, linking them to schizophrenia-related hypofrontality.

PET Brain imaging of α7-nAChR with ASEM: Reproducibility, occupancy, receptor density, and changes in schizophrenia

This study uses PET imaging with [18F]ASEM to assess reproducibility, occupancy, receptor density, and changes in a7-nAChR in schizophrenia patients.

NMR Analysis Of The Interaction Of Ethanol With The Nicotinic Acetylcholine Receptor

The paper estimates the dissociation constant and binding free energy of ethanol binding to nicotinic acetylcholine receptor using NMR T1 titration data and nonlinear regression analysis.