Nicotinic Acetylcholine Receptors Study

Deletion induced splicing in RIC3 drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes

The paper investigates how a deletion in RIC3 affects splicing and nAChR regulation in human astrocytes under ER stress, identifying potential therapeutic targets.

A Novel and Functionally Diverse Class of Acetylcholine-gated Ion Channels

The paper identifies new inhibitory acetylcholine-gated ion channels in C. elegans with diverse ligand binding properties and reveals neurons expressing both excitatory and inhibitory channels.

CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission

This study identifies CASK and FARP as scaffolding proteins that localize post-synaptic ACh receptors, enhancing cholinergic transmission in C. elegans.

Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging

The paper investigates how nicotine and varenicline distribute in brain cells by combining in vitro and in vivo imaging, finding that varenicline is trapped in 4{beta}2R-containing Golgi satellites, leading to slow release.

Evaluation of an image-derived input function for kinetic modeling of nicotinic acetylcholine receptor-binding PET ligands

This study evaluates an image-derived input function for PET ligand kinetic modeling in mice, showing improved quantification compared to reference tissue methods for nicotinic receptor-binding tracers.

A conserved role of α2δ subunit of calcium channel in nicotine motivated behavior.

The paper identifies the conserved role of α2δ subunits of calcium channels in nicotine-motivated behavior across species using C. elegans and human GWAS data.

Reconstitution of an N-AChR from Brugia malayi

The paper reconstitutes the N-AChR from Brugia malayi in Xenopus oocytes, showing that its response is progressively reduced compared to related species and requires accessory proteins.

A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

This study shows that tonic activation of 4β2 nicotinic acetylcholine receptors on GABAergic interneurons primes feedforward inhibition, shaping striatal output timing and synaptic plasticity.

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

This study identifies Drosophila nAChR subunits interacting with insecticidal toxins using CRISPR/Cas9 and pull-down assays, providing insights for insecticide design.

Duplicated binding site for RIC-3 in 5-Hydroxytryptamine Receptors Subtype 3

The paper identifies two RIC-3 binding sites in 5-HT3A subunits, with a duplicated motif, and shows their role in modulating surface expression.

4R-Tobacco-Cembranoid is a Positive Allosteric Modulator of the Alpha7 Nicotinic Acetylcholine Receptor that modulates inflammation-induced thermal hypersensitivity in mice

This study identifies 4R-Tobacco-Cembranoid as a positive allosteric modulator of 7nAChRs that reduces thermal hypersensitivity and inflammation in mice, with sex-specific effects.

Nicotinic signaling is required for motor learning but not rehabilitation after spinal cord injury

This study shows that nicotinic signaling is necessary for motor learning but not for rehabilitation of previously learned movements after spinal cord injury.

Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons

The paper identifies Chrna5-expressing super-responder subplate neurons using transgenic mice and single-cell transcriptomics, revealing unique lynx prototoxin gene expression and potential therapeutic targets for attention disorders.

Channel opening duration in adult muscle nAChRs determined by activated external ACh binding site

The paper measures channel opening durations in nicotinic acetylcholine receptors (nAChRs) by recording single-molecule currents and finds that agonist binding at specific sites determines opening durations and burst patterns.

Nicotinic modulation insecticides act on diverse receptor subtypes with distinct subunit compositions

This study identifies distinct nAChR subunit compositions responsible for the toxicity of various nicotinic modulation insecticides in Drosophila melanogaster.

NAChRDB: A Web Resource of Structure-Function Annotations to Unravel the Allostery of Nicotinic Acetylcholine Receptors

NAChRDB provides a web resource with curated residue-level functional annotations and 3D visualization for neuromuscular nAChRs to aid in understanding their allosteric mechanisms.

Optical Control of Invertebrate nAChR and Behaviors with Dithienylethene-Imidacloprid

This paper develops a photochromic ligand, DitIMI, that modulates invertebrate nAChR activity and behavior in mosquitoes and cockroaches, and serves as a tool for high-throughput screening.

α3β4* Nicotinic acetylcholine receptors strongly modulate the excitability of VIP neurons in the mouse inferior colliculus

This study shows that 3β4* nAChRs strongly excite VIP neurons in the mouse inferior colliculus, influencing auditory processing through prolonged excitability.

Nicotinic acetylcholine receptor partial antagonist polyamides from tunicates and their predatory sea slugs

The paper identifies molleamine C as a partial antagonist of nicotinic acetylcholine receptors with potential for neuroactive drug development.

The HSPG Syndecan is a core organizer of cholinergic synapses in C. elegans

This study identifies SDN-1 as a critical organizer of cholinergic synapses in C. elegans by clustering AChRs and interacting with synaptic components.

A C. elegans genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle function

The paper identifies genes affecting levamisole sensitivity in C. elegans by RNAi screening, revealing roles in muscle function and metabolic processes.

Cholinergic signalling at the body wall neuromuscular junction couples to distal inhibition of feeding in C. elegans

The paper shows that cholinergic signaling at the body wall neuromuscular junction in C. elegans inhibits feeding by coupling with locomotion control.

Loss of choline agonism in the inner ear hair cell nicotinic acetylcholine receptor linked to the α10 subunit

The paper investigates the reduced efficacy of choline as an agonist at mammalian 910 nicotinic acetylcholine receptors, linking this change to evolutionary adaptations in the 10 subunit.

Mechanism of gating and partial agonist action in the glycine receptor

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

Selective co-activation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction

Muscle Van Gogh-like 2 shapes the neuromuscular synapse by regulating MuSK signaling activity

This study identifies Vangl2 as a regulator of MuSK signaling in neuromuscular synapse formation, showing its role in AChR accumulation and NMJ stability.

Unravelling the molecular players at the cholinergic efferent synapse of the zebrafish lateral line

The paper identifies α9-containing nicotinic acetylcholine receptors (α9* nAChRs) at the zebrafish lateral line efferent synapse, showing they mediate ACh-induced inhibition of hair cell activity through SK potassium channels.

Full activation of an α7-α3β4 nicotinic receptor complex decreases desensitization receptor in human chromaffin cells

The paper shows that full activation of an α7-α3β4 nicotinic receptor complex in human chromaffin cells reduces desensitization, while choline limits current increases, and this interaction weakens with age.

Chrna5 is essential for a rapid and protected response to optogenetic release of endogenous acetylcholine in prefrontal cortex

This study shows that Chrna5 enables rapid and resilient cholinergic responses in prefrontal cortex, crucial for attention, and identifies NS9283 as a potential treatment for Chrna5 disruption.

Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε

This study shows that PKCε regulates Chrna6 and Chrnb3 expression differently in male and female mice, affecting nicotine and alcohol behavior.