Yersinia bacterium, plague, ectoparasites research

The transcriptional response of Yersinia pseudotuberculosis to macrophage-released metabolites during growth within synthetic microcolonies

This study investigates how Yersinia pseudotuberculosis responds to macrophage-released metabolites during growth in synthetic microcolonies, identifying nitrosative stress and itaconate as key factors.

A Refined Phylochronology of the Second Plague Pandemic in Western Eurasia

This paper uses genomic and historical data to refine the timeline and origin of the Second Plague Pandemic in Western Eurasia.

Host CD59 Potentiates the Type III Secretion System in Yersinia pseudotuberculosis

This study shows CD59 supports Yersinia pseudotuberculosis T3SS function by maintaining plasma membrane dynamics and lipid microdomain organization.

Combination of live attenuated and adenovirus-based vaccines completely protects interferon gamma (IFNγ) knockout mice against pneumonic plague

This study evaluates two live attenuated plague vaccines and their combination with an adenovirus-based vaccine in IFNγ knockout mice, showing complete protection against pneumonic plague.

Lethal Plague Outbreaks in Lake Baikal Hunter-gatherers 5500 Years Ago

This study identifies the oldest known plague strains in Lake Baikal hunter-gatherers 5500 years ago, showing early outbreaks were lethal and challenged the idea that agriculture was necessary for plague epidemics.

Application of long-read sequencing for genotyping, epigenetic profiling and surveillance of Yersinia pestis isolates from natural foci and disease outbreaks in Central Asia

This study uses long-read sequencing to genotype and epigenetically profile Yersinia pestis isolates, revealing genetic diversity and host adaptation mechanisms.

A type IVB secretion system contributes to the pathogenicity of Yersinia pseudotuberculosis strains responsible for the Far East scarlet-like fever

This study identifies the Y. pseudotuberculosis T4BSS as a virulence factor contributing to FESLF pathogenicity through immune modulation during oral infection.

Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.

RfaH is Essential for Virulence and Adaptive Responses in Yersinia pseudotuberculosis Infection

This study shows RfaH is essential for Yersinia pseudotuberculosis virulence and adaptation, as its loss reduces virulence and impairs persistent infection.

TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral Yersinia infection

This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.

Yersinia actively downregulates type III secretion and adhesion at higher cell densities

This study shows Yersinia enterocolitica suppresses T3SS expression and adhesion at high cell densities through VirF downregulation and CsrBC-mediated mechanisms.

Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage

The paper presents a Yersinia pestis genome from a Bronze Age sheep, showing it belongs to a lineage previously only found in ancient humans and suggests transmission via livestock.

In-host evolution of Yersinia enterocolitica during a chronic human infection

This study tracks genetic and phenotypic changes in Yersinia enterocolitica during a chronic human infection, revealing host-adaptive mutations and antibiotic resistance mechanisms.

The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria

This study identifies PAPI (encoded by pcnB) as essential for maintaining virulence and AMR plasmid copy number, stability, and bacterial virulence in Yersinia and Shigella.

Contribution of the Type 3 Secretion System to immunogenicity of a live Yersinia pseudotuberculosis plague vaccine

This paper evaluates a modified Yersinia pseudotuberculosis vaccine lacking the Type 3 Secretion System, showing reduced protection but increased safety compared to the original strain.