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Evaluating Preservation Techniques for Long-Term Stability of 3D Bioprinted Liver Scaffolds

This study evaluates -80°C preservation of 3D bioprinted liver scaffolds using GelMA and decellularized liver ECM, showing ~80% cell viability and preserved structure but highlighting sensitivity to preservation-induced injury.

The effect of microstructural variations in tendon and ligament on diffusion tensor MRI

This study investigates how microstructural variations in tendon and ligament affect diffusion tensor MRI metrics through simulations of fiber networks.

Integrated multi-modal data analysis for computational modeling of healthy and location-dependent myocardial infarction conditions in porcine hearts

The paper develops porcine ventricular digital twins using multi-modal data to study myocardial infarction effects on cardiac function and ECG patterns.

Genetically Engineered Biomimetic Nanozymes Reprogram Immune Niches to Intercept Colitis-Carcinoma Transition

This paper develops genetically engineered nanozymes that target immune niches to prevent colitis-associated colorectal cancer by reducing oxidative stress and immune cell infiltration.

Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

This study uses micropatterned cardioids to investigate mesoderm-endoderm interactions in heart development, finding that pattern size affects cavity formation and signaling.

Proton sponge or membrane fusion? Endosomal escape of siRNA polyplexes illuminated by molecular dynamics simulations

This study uses molecular dynamics simulations to analyze endosomal escape mechanisms of siRNA polyplexes and a lipid nanoparticle, identifying key interactions that correlate with in vitro performance.

Paracrine Factor Local Gradient-Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion-Induced Proliferation

This paper develops a paracrine factor local gradient system to create vascularized hepatocyte tissues that proliferate under perfusion.

Automated culture and monitoring of a high-throughput human heart-on-a-chip

This study develops an automated high-throughput heart-on-a-chip system using iPSC-derived cardiomyocytes and GCaMP6f for monitoring, showing a temperature-dependent decrease in beat rate.

Development and Validation of a Continuous Real-Time Optical Sensor for Indocyanine Green Clearance Measurement During Ex-Vivo Perfusion of Human Livers

This paper develops and validates a continuous real-time optical sensor for measuring indocyanine green clearance during ex-vivo liver perfusion, showing high accuracy compared to spectrophotometry.

A nicotine biosensor derived from microbial screening

The paper develops a nicotine biosensor using a microbial-derived redox enzyme, demonstrating detection over a clinically relevant range.

Mechanistic insights into the color transformation of a non-FRET substrate for RNase activity detection

This paper identifies the mechanism of color change in DNA/AgNC substrates upon nucleolytic cleavage and demonstrates their application in sensitive virus detection.

Synergistic Electroceutical-Glucocorticoid Intervention Mitigates Dexamethasone-Induced Muscle Atrophy in Aging Skeletal Muscle

This study shows electroceutical treatment reduces DEX-induced muscle atrophy in both young and aged skeletal muscle cells and mice, improving muscle fiber size and gene expression.

Clamp the LAMP: a photoelectrochemical platform for KRAS mutation detection via wild-type blocking

This paper introduces a photoelectrochemical platform for KRAS mutation detection that uses molecular suppression of wild-type alleles to enhance sensitivity and specificity.

Modeling and optimization of a central diamond shape threefold hexagon metamaterial sensor for glioblastoma cell detection

This paper designs a terahertz metamaterial absorber sensor to detect glioblastoma cells using microwave imaging, showing high absorption and polarization conversion efficiency.

Dried-bakery waste as a substrate for n-caproate and n-caprylate production via chain elongation: bakeroate

This study converts bakery waste into n-caproate and n-caprylate using microbial chain elongation, achieving 30-35% carbon conversion with lactate as a superior intermediate.

Ultra-low-illumination, high-fidelity longitudinal monitoring of cerebral perfusion via deep learning-enhanced laser speckle contrast imaging

This paper introduces TunLSCI, a deep learning method that enhances low-illumination laser speckle contrast imaging for high-fidelity, long-term cerebral perfusion monitoring in mice.

Spatial transcriptomics for gene discovery identifies Slc13a5 as a modulator of bone mechanoadaptation

This study uses spatial transcriptomics to identify Slc13a5 as a regulator of bone mechanoadaptation, showing its role in mineralization and resorption under mechanical loading.

Multi-material biomaterial model of scaffold-defect integration at the wound margins

The paper develops a 3D in vitro model to study stromal cell migration and biomaterial integration for craniomaxillofacial defect repair.

Anti-Buoyancy Trap for Long-Term Quantitative Density Profiling of Adipocyte Spheroids

The paper quantifies density changes in adipocyte spheroids over time and introduces an anti-buoyancy trap to enable long-term, reproducible analysis of their physical properties.

Human decellularized extracellular matrix from adipose tissue is a permissive microenvironment for pancreatic organoids generation

This study develops a decellularized adipose tissue-derived hydrogel (atdECM) that supports pancreatic organoid growth with improved transcriptional profiles compared to Matrigel.