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Arrayed hydrogels pair whole-cell imaging with single-cell mass spectrometry proteomics

This paper introduces a platform called ProteoParcel that combines whole-cell imaging with single-cell mass spectrometry proteomics for breast cancer cells.

Cyclic-thiourea ionizable lipids program multilamellar mRNA-LNPs for sustained expression, frozen-storage stability and potent vaccine immunotherapy

This paper introduces a cyclic-thiourea ionizable lipid (HI-62) that forms multilamellar mRNA-LNPs with sustained expression, stability, and potent vaccine immunotherapy effects.

Multidimensional T1-T2 Relaxation Imaging In Vivo on a Portable 0.064~T MRI Scanner

This paper demonstrates whole-brain multidimensional T1-T2 relaxation imaging on a portable 0.064 T MRI scanner, showing that joint distributions provide additional information beyond single-value relaxation maps.

Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach

This paper develops dual-thread wearable biosensors using computerized embroidery for electrocardiography and ion sensing, demonstrating improved electrochemical performance and compatibility with scalable fabrication.

Capturing Regional Variation in Aortic Mechanics: Dual-Estimation Method for Material Parameter Identification and Biological Correlation

The paper introduces a dual-estimation framework to identify aortic material parameters and correlate them with biological variation using data from Wistar rats.

Democratizing Agentic Access to Bioinformatics and Biopharmaceutical Databases and Analyses with BioMCP-TS

BioMCP-TS provides an open-source server enabling AI agents to access and analyze biomedical databases and run analyses without complex dependencies.

Eye-tracked Maxwellian illumination system for power-efficient retinal stimulation

The paper presents a retinal stimulation system using eye tracking and a VCSEL array to achieve high optical efficiency and a wide field of view.

Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics

This study engineers segmented poly(A) tails with microRNA target sites to enable tissue-specific regulation of mRNA-LNPs, showing position-dependent expression control in vitro and in vivo.

Generalizable Cysteine Quantification in Pea Cultivars from SERS Spectra Using AI

The paper uses AI to quantify cysteine in pea cultivars from SERS spectra, finding that a 1D-CNN outperforms other models in accuracy and generalization.

Out-of-sight partners: autonomous wearable supernumerary limbs for dynamic co-manipulation

This study demonstrates that humans can effectively collaborate with autonomous wearable robotic limbs during dynamic tasks without visual feedback, achieving reliable task completion and high perceived safety.

Computationally inspired glycoengineering to maximise mAb β4-galactosylation

This paper describes a dual genetic engineering strategy to enhance mAb β4-galactosylation in CHO cells, achieving over 90% galactosylation and reducing Man5 glycans without affecting mAb titre.

Patient-Derived Organoids as a Model to Understand Tumor Microenvironment-Driven Nano-Bio Interactions - A Framework Towards Improved Nanomedicine Translation

This paper uses patient-derived colonic organoids to study how tumor microenvironment proteins affect nanoparticle uptake and delivery, showing improved targeting of chemoresistant cells.

Selective Activation of Nerve Fiber Subpopulations with Intrafascicular Stimulation

This study demonstrates that intrafascicular electrode placement and electric field steering can selectively activate specific nerve fiber subpopulations, improving selectivity in peripheral nerve stimulation.

Cytoskeletal disassembly by optogenetic control of RhoA signaling termination

This study introduces an optogenetic tool to control RhoA signaling termination and shows it is faster than passive disactivation, revealing an asymmetry between activation and termination kinetics.

Advancing Knotted Protein Design with ESM3: Guided Generation and Topological Insights

This study uses ESM3 to generate knotted proteins, finding high success rates with guided decoding and robustness in real knotted proteins.

Amplified genome editing by in vivo editor production

This study demonstrates that in vivo delivery of genome editing enzymes can be amplified through cell-to-cell transfer, significantly increasing editing efficiency in mice.

De Novo Design and AlphaFold3 Evaluation of Protein Binders Targeting Specific Sites of MAP4K4

The paper designs small protein binders targeting specific MAP4K4 sites using computational tools and evaluates their binding using AlphaFold3, finding high-confidence candidates with novel sequence space solutions.

Modelling and measuring effects of shear stress in extrusion bioprinting of endothelial- epithelial cell co-cultures

The paper develops a workflow combining rheology, CFD modeling, and experiments to assess shear stress effects on cell viability during extrusion bioprinting of co-cultures.

Positive joint work redistribution in running: the role of plantar flexor fatigue and the effect of advanced footwear technology

This study examines how plantar flexor fatigue and footwear technology affect joint work redistribution during running.

Human knee osteoarthritis patient-specific cartilage-on-a-chip model captures donor differences to stressors and treatments

This paper develops a patient-derived cartilage-on-a-chip model for KOA that captures donor differences in response to stressors and treatments.