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Vascularizing neurospheroids to probe vascular contributions to α-synuclein pathology in Parkinson's disease

This study develops a vascularized brain model to investigate how vascular dysfunction contributes to Parkinson's disease pathology by inducing α-synuclein aggregation in neurons.

Extracellular matrix composition is associated with tissue-specific decellularization susceptibility and mechanical remodeling across human urogenital tissues

This study shows that ECM composition determines tissue-specific decellularization outcomes and mechanical properties, advocating for ECM-focused quality assessment in regenerative medicine.

LNP-mediated BCL11A Editing Corrects Sickling Phenotypes and Preserves HSPC Fitness Compared to Electroporation

This study compares LNP and electroporation for delivering CRISPR to HSPCs, finding LNPs provide better cell viability and HbF induction with lower toxicity.

2-Deoxyglucose dendrimer-enabled niclosamide delivery to FRβ-expressing macrophages alleviates endometriosis progression and associated hyperalgesia

This paper develops a targeted nanotherapeutic, FA-2DG-D-Niclo, which delivers niclosamide to FRβ-expressing macrophages, reducing endometriosis lesions and hyperalgesia in mice.

Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis

This study compares the targeting efficiency of Ang2 and TAT peptides via intravenous and intrathecal routes in leptomeningeal disease models, finding TAT achieves better targeting in specific regions.

Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation

This study shows that the outer polyion layer of layer-by-layer nanoparticles affects protein corona formation, which influences their biodistribution and therapeutic efficacy.

DyAb: sequence-based antibody design and property prediction in a low-data regime

DyAb predicts antibody properties and designs new sequences with high binding affinity using a low-data approach.

Decoupling Detection and Classification to Improve Morphological Phenotype Analysis of Sickle Red Blood Cells in Full-Scope Microscopy

This paper improves sickle cell disease morphology analysis by combining a YOLO detector with a DenseNet classifier for accurate detection and classification of red blood cell morphologies in full-scope microscopy images.

A Translational Platform for Brain-Computer Interfaces and Adaptive Neuromodulation: Technical Characterization, Long-Term Validation, and Implementation of the CorTec Brain Interchange--BCI2000 Ecosystem

The paper develops and validates an open-source ecosystem for implantable brain-computer interfaces and adaptive neuromodulation, demonstrating its capabilities through preclinical and human studies.

Doxorubicin-induced Cardiotoxicity is Propagated by Paracrine Signaling through Small Extracellular Vesicles

This study shows DOX-induced cardiotoxicity spreads via paracrine signaling through extracellular vesicles, with plasma EV miRNA profiles indicating risk stratification and potential biomarkers for early detection.

Aiptasia larvae are phenotypically validated as a model of coral bleaching using high-throughput machine-learning image analysis

This paper validates Aiptasia larvae as a coral bleaching model and introduces SYMPHONY, an ML pipeline that efficiently identifies algal localization in larvae under heat stress.

Directed Evolution in Codon Space

This paper applies directed evolution to codon space, improving recombinant expression of 74% of tested therapeutics without altering protein sequence.

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

This paper develops programmable protein degraders (uAbs) that selectively knock down pathogenic β-catenin in vitro and in vivo, reducing tumor cell survival and proliferation.

Using CarboTrace 480 to detect protoplastation in pigment deficient mutant of Chlorella sorokiniana

This study uses Carbotrace 480 to detect protoplasts in a pigment-deficient mutant of Chlorella sorokiniana, identifying Snailase as the most effective enzyme for cell wall degradation.

Tracking breast cancer progression using Methylscape

This study uses Methylscape to track breast cancer progression by detecting epigenetic changes during EMT and developing a low-cost platform for monitoring.

Biophytometallurgy: biomining metals from plant resources

This study investigates metal release from plants using biophytometallurgy, showing that microbial activity influences rare earth element redistribution without requiring thermal processing.

Dual Traditional Chinese Medicine-Preconditioned Stem Cell Secretomes in Coaxial Electrospun Nanofibers Synergistically Accelerate Diabetic Wound Regeneration

This paper develops a coaxial nanofiber scaffold delivering TCM-preconditioned stem cell secretomes to accelerate diabetic wound healing.

Magnetic particle imaging reveals heterogeneous retention, leakage and redistribution of nanoparticles following intratumoral injection

This study uses magnetic particle imaging to track nanoparticle distribution and fate after intratumoral injection, revealing heterogeneous retention, leakage, and systemic redistribution.

The Neural Impact Score benchmarks drugs in Multi-Region Brain Organoids

The paper introduces the Neural Impact Score (NIS) to evaluate drug effects on brain organoids across multiple biological categories, demonstrating its utility in cross-species drug benchmarking.

Electrophysiological profiling of hiPSC-derived neurospheres using a novel NeuroMPS with integrated electrodes

This paper develops a novel NeuroMPS platform to monitor neuronal network dynamics in 3D human iPSC-derived neurospheres with high electrophysiological resolution and multimodal analysis.