Discover, rate, and discuss biology preprints.

This paper introduces PIGEON-FEATHER, a method to calculate free energies of protein conformational ensembles from HX/MS data, revealing evolutionary differences in enzyme inhibitors and ligand-induced reweighting in a protein-DNA complex.

This paper introduces a framework to generate branching morphologies using fast-marching algorithms with feedback mechanisms, demonstrating its ability to create realistic 2D and 3D structures.

The paper introduces Prodan-based solvatochromic probes for imaging organelle polarity, showing organelle-specific polarity changes under starvation.

The paper uses Region Capture Micro-C to study microcompartment formation during mitosis-to-G1 transition, finding they form in prometaphase and are influenced by chromatin compaction and loop extrusion.

The paper develops a computational method to measure membrane thickness in cryo-electron tomograms, revealing systematic variations across organelles and supporting hydrophobic matching models.

The paper introduces a classical continuum model compatible with quantum mechanics to simulate mechanical responses of cell membranes and crosslinkers, reproducing experimental data on adhesion and membrane dynamics.

The paper develops a computational model of Drosophila border cell migration that integrates intercellular forces and shape changes, validated with live imaging data, revealing new insights into migration dynamics in heterogeneous environments.

This study uses optical calcium release to investigate Tcb2 self-assembly in Tetrahymena, identifying D184 as the key calcium binding site for assembly.

This study describes the structural features of FusB-ferredoxin and FusB homodimer complexes, proposing a mechanistic model for ferredoxin import in Pectobacterium spp.

This paper introduces a computational method to predict TCR-pMHC interactions and design immunogenic peptides, achieving high accuracy and demonstrating success in T-cell activation.

The paper uses mass photometry to analyze how small-molecule inhibitors disrupt GNE oligomerization, finding concentration-dependent destabilization and competitive binding.

The paper shows Piezo1 senses viscoelasticity in soft ECMs and identifies transcriptomic changes in MSCs in response to matrix properties and Piezo1 activity.

This study uses multiscale simulations to investigate polyglutamine aggregation mechanisms and how the N17 flanking domain influences fibril polymorphism in Huntingtons disease.

This study shows that protein condensates and clathrin assembly regulate each other during clathrin-mediated endocytosis, enhancing vesicle formation while controlling condensate growth.

This paper identifies a single residue, H410, that determines how TRPV1 interacts with phosphoinositides, revealing a two-site binding mechanism for PI(4,5)P2 regulation.

This paper develops a hybrid neural-symbolic framework to uncover the mathematical principles linking cellular energetics to genetic regulation using simulated time-series data.

This study uses molecular dynamics simulations to investigate how dye conjugation affects the biophysical properties of virus-like particles, revealing structural and electrostatic changes that influence superradiance.

This study shows that mechanical compression and vibration from magnetic microdiscs reduce glioblastoma cell aggressiveness on soft substrates by impairing proliferation, motility, and acto-myosin function.

Amyloid Explorer provides a standardized, thermodynamically annotated atlas of amyloid fibril structures, revealing conserved assembly rules and enabling mechanistic insights.

This study shows that hydrophobic asymmetry in non-charged protein condensates creates electric potential gradients, enabling potential-dependent chemistry.