Discover, rate, and discuss biology preprints.

The paper applies the James-Stein estimator to kinematic and metabolic human data to improve accuracy and reduce sample requirements.

This study presents cryo-EM structures of sHSPs in apo and client-bound states, revealing mechanisms of client sequestration and polydispersity in sHSP complexes.

This study investigates the structural dynamics of DENV2 NS5 interacting with SLA using SPR, HDX-MS, computational modeling, and cryoEM, revealing conformational changes and a conserved binding mode.

This study uses computational modeling to analyze binding mechanisms of four antibodies against SARS-CoV-2 Omicron variants, revealing distinct dynamic and evolutionary adaptations that influence immune escape.

This study quantifies charge-based transient interactions in intrinsically disordered proteins, showing they shape conformational behavior and are enriched in specific biological functions.

This study shows that curcumin modulates huntingtin aggregation, reducing cellular stress by altering fibril structure and metabolic properties.

The paper introduces a computational framework linking chromatin structure to gene regulation using polymer models and Hi-C data, showing how CTCF deletion affects gene expression in limb development.

This paper proposes a mechanism to achieve noise-resistant coherent oscillations by coupling a Markovian system to a non-Markovian system, validated through a trimolecular reaction system.

This study shows how chirality and spin enhance protein-DNA complex stability through the chiral-induced spin selectivity effect.

This study investigates how StarD4 recognizes PIP2 subtypes and how this recognition affects cholesterol transport kinetics through molecular dynamics and machine learning analysis.

The paper shows phosphorylation of Ser81 in AGT inactivates the enzyme and mimics some PH1-causing mutations.

The paper identifies 3D topological defects and quasi-long-range order in glioma tumors, linking them to tumor aggression and cell density regulation.

This paper presents a streamlined method for (an)aerobic vitrification of oxygen-sensitive proteins using an automated device, enabling high-resolution cryoEM structure determination.

This study shows that the picornavirus 3C protease binds RNA and induces liquid-liquid phase separation, which may have implications for viral replication and stress granule dynamics.

This study investigates how TLR4 and FcγR interact on macrophage surfaces through nanoclusters to enhance inflammatory responses and signaling.

This paper introduces two optical sectioning methods for RICM to reduce background noise and improve image quality in complex biological samples.

This study demonstrates that large particles can be controlled and orthogonally partitioned into biomolecular condensates through strong particle-condensate interactions, using polymer nanoparticles with tailored surface chemistries.

This paper develops a continuum framework to study stress anisotropy in 3D curved biological layers, showing how curvature and cell mechanics lead to irregular cellular shapes like scutoids.

This study develops and characterizes six nanobodies as potential therapeutics for PH1 by targeting misfolded AGT variants, showing high affinity and functional enhancement in cellular models.

This paper introduces Bayes-smRD, a method to analyze single-molecule reaction-diffusion using photon arrival data, revealing molecule-specific properties with reduced data and photodamage.