B. Liu

This study improves targeted insertion in plants using chemically protected dsODNs with 5' 1-nt overhangs, achieving directional and precise insertions for gene tagging and cis-regulatory engineering in Setaria viridis and rice.

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

This study shows that high-altitude hypoxia induces splenic macrophage ferroptosis, reducing erythrophagocytosis and contributing to high-altitude polycythemia.

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

This study characterizes a mouse model of ICF syndrome, revealing that Zbtb24 deficiency leads to hypogammaglobulinemia via enhanced CD19 activation and IL-5 signaling.

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

This study examines how life stage and vaccination affect the gut microbiome of Atlantic salmon, finding that sub-adults have higher diversity and a core microbiome, while vaccination reduces diversity and increases individual variation.

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

The paper describes a new species of vampire squid, Vampyroteuthis pseudoinfernalis, distinguished by morphological and genetic differences from the known species Vampyroteuthis infernalis.

This study identifies Tr1 cells in glomerulonephritis, showing their suppressive function and potential as therapeutic targets.

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

This study examines how nutrient scarcity affects the interaction dynamics between Bacteroides thetaiotaomicron and Roseburia intestinalis using in vitro experiments and computational modeling.

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

The paper compares TCR repertoires of regulatory and effector T cells in non-obese diabetic mice, showing similar reactivity but differing suppressive capacity linked to TCR affinity.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

This study investigates how DNA mismatches affect nucleosome mechanical stability and DNA exposure using single-molecule techniques, finding that C-C mismatches increase stability and reduce accessibility.

The paper investigates how pH changes affect microbial chain elongation communities in bioreactors, finding functional redundancy allows recovery of fermentation functions despite shifts in community composition.

The paper identifies MYA1 as a Myosin XI that forms cortical assemblies with microtubule-associated proteins to guide the phragmoplast during cytokinesis in Arabidopsis thaliana.

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

The paper identifies an alternative pathway for malonyl-CoA production using oxaloacetate dehydrogenase in Streptomyces, enabling efficient bioproduction of malonyl-CoA-derived chemicals in E. coli.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This paper identifies CWLP and PRP940 as plasma-membrane nanodomain proteins that interact with aquaporins and PP2A, enhancing dehydration tolerance in plants.

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.