F. Zhang

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

The paper introduces CeMbio, a simplified natural microbiota for C. elegans, enabling causal studies of host-microbiome interactions through a resource with culturable strains and associated tools.

This meta-analysis compares oncologic outcomes of T1 glottic carcinoma treated with transoral laser surgery or linear accelerator radiotherapy, finding better overall survival and laryngeal preservation with surgery.

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

This paper develops a multiplexed CRISPR/Cas9 system with Trex2 exonuclease to improve genome editing efficiency in Setaria viridis, achieving high mutation rates and MMEJ-mediated repair.

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

This study links the evolution of red colour vision in lycaenid butterflies to coordinated rhodopsin tuning, showing how molecular changes in multiple opsins expand spectral sensitivity for visual tasks.

This study identifies genomic features distinguishing highly pathogenic SARS-CoV-2, SARS-CoV, and MERS-CoV from less pathogenic coronaviruses using comparative genomics and machine learning.

The paper shows WOX9 negatively regulates leaf blade outgrowth in Medicago truncatula and Nicotiana sylvestris by antagonizing STF and LAM1, with STF repressing WOX9 activity to maintain proper blade development.

This paper develops a novel HER2-targeted ADC, CAT-01-106, showing improved efficacy and tolerability compared to T-DM1 at equivalent payload dosing.

This study investigates the pH and heparin chain length dependence of GMCSF-heparin binding using NMR, SPR, and molecular docking, revealing dynamic structural changes and a proposed binding mechanism.

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

This study shows that CRISPR/Cas9-generated GHRH-/- mice have reduced body weight, improved insulin sensitivity, and altered metabolism, consistent with previous findings on growth hormone deficiency.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

The paper introduces oxView and open-source tools for visualizing and analyzing large DNA/RNA nanostructures simulated with oxDNA, enabling design, optimization, and structural analysis.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

The paper shows that diatoms adjust their movement behavior to optimize resource exploitation in complex environments through experiments and modeling.

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

The paper identifies endo-acting O-glycanases in gut bacteria that initiate mucin breakdown, challenging the current model of exo-acting glycosidases.

This study shows decorin reduces high glucose-induced apoptosis and oxidative stress in lens epithelial cells by inhibiting the p22phox-p38 MAPK pathway.

The paper investigates the evolutionary origins of epidemic potential in human RNA viruses, finding that most transmissible lineages evolved from non-human viruses.

The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.

This paper introduces CLEAR-dPCR, a lossless and contamination-free digital PCR technology that improves accuracy and dynamic range compared to existing platforms.

This study tracks the development of a potent ZIKV-specific antibody in a convalescent human, revealing limited somatic hypermutation and high germline identity.

This study identifies extensive genetic diversity of bat-borne polyomaviruses and reports three inter-family host-switching events, challenging the notion of strict host restriction in mammalian PyVs.

This study identifies aroma-active compounds in three delicious apple juice cultivars using GC-MS, GC-O, and OAV, finding key contributors to the juice's aroma.

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

This study identifies PRH1 as a target of ARF7 and LBDs in auxin signaling, showing its role in lateral root development through interaction with GATA23.

The paper identifies CP77 as a third orthopoxvirus inhibitor of rodent SAMD9L, showing it uniquely targets Chinese hamster SAMD9L and enables viral replication.