H. Lin

This paper develops a combined imaging system for live cell nanoscale imaging, enabling the simultaneous quantification of molecular targets, 3D cell morphodynamics, and intracellular organelle tracking.

The paper visualizes limonene synthesis metabolons in engineered E. coli using hyperspectral SRS microscopy and confirms colocalization with limonene synthase.

The paper develops MILL, a technique to rapidly create 3D micro-patterned flow channels that mimic in vivo fluid shear stress environments, enabling real-time study of cell adhesion and translocation.

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

This study shows that both tree species and genetic diversity increase productivity through functional diversity and trophic feedbacks, with genetic diversity effects varying between monocultures and mixtures.

The paper presents a standardized protocol and bioinformatic pipeline for detecting and quantifying mercury methylation genes (hgcAB) in metagenomes, showing comparable efficiency between single and co-assembly approaches.

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

This study uses calcium imaging to compare calcium oscillations, waves, and network dynamics in human islets from donors with and without type 2 diabetes, finding altered glucose responses and network structure in diabetic islets.

This paper engineers RNA viruses with an unnatural amino acid to create adjustable immune responses in mice, demonstrating potential for vaccine development.

This paper presents a method using unnatural amino acid-engineered drug-resistant influenza virus to sterilize drug-resistant strains, validated in vitro and in animal models.

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

This study shows TRIM47 enhances endothelial activation and pulmonary inflammation by promoting K63-linked ubiquitination of TRAF2, leading to NF-κB and MAPK pathway activation.

This study identifies two E protein inhibitors for SARS-CoV-2 using structural modeling and virtual screening, including a compound in clinical trials.

This study identifies WAPO-A1 as the causal gene for a QTL affecting spikelet number per spike in wheat and shows that the H2 haplotype significantly increases grain yield.

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

This paper develops hybrid nanovesicles combining tumor exosomes and AIE nanoparticles for enhanced NIR-II imaging and photothermal therapy of tumors.

The paper shows that IGF2BP2 degradation of ATP6V1A transcript, driven by SIRT1 down-regulation and acetylation, impairs lysosomal function and promotes cancer progression.

This study identifies a novel β-arrestin-2-mediated signaling pathway that mediates aPC/PAR1's anti-apoptotic effects in endothelial cells.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This study investigates the genetic and physical interactions between SQUAMOSA and SVP MADS-box proteins in wheat spike development, showing their roles in regulating meristem transitions and floral development.

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

This paper introduces statistical measures for spatial rotations and projection directions in cryoEM, accounting for molecular symmetry, and implements them in an open-source Python package.

This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study uses genetic selections to uncover the molecular mechanism of the HitRS signal transduction system in Bacillus anthracis, identifying key residues and interactions essential for TCS function.