H. Sun

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

This study shows that high-frequency soil polarization (ECsoil) can accurately measure root volume and distribution in the field, with potential for noninvasive root phenotyping.

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

This study identifies AdgB and AdgI as key proteins in the Variovorax auxin-degradation operon, revealing their roles in IAA uptake and conversion to oxIAA, and demonstrates the operon's potential for IAA regulation in E. coli.

The paper analyzes viral genomes from four strains of Rhizoctonia cerealis, identifying 131 novel or unclassified mycoviruses and proposing new taxonomic classifications.

This study identifies the sRNA B11 as a regulator of gene expression and virulence in Mycobacterium abscessus, showing it affects colony morphology, inflammation, antibiotic resistance, and secretion system activity.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

This study identifies dynein-mediated trafficking and degradation of nephrin as a key mechanism in diabetic podocytopathy, showing increased dynein expression and its role in nephrin mistrafficking.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

This study identifies ATF3 as a key regulator that preserves skeletal muscle stem cell quiescence by preventing premature activation and maintaining genome stability.

The paper determines high-resolution X-ray structures of NaK mutants mimicking AMPA receptor selectivity filters and reveals their ion selectivity and structural asymmetry through MD simulations and electrophysiology.

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

This study shows that gestational early-time restricted feeding leads to sex-specific glucose intolerance in adult male mice, but not females, after a high fat, high sucrose diet.

This paper identifies compounds that inhibit T4SS-mediated effector delivery in pathogens, offering potential for pathogen-specific therapeutics.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.