H. Sun

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

The paper introduces WormCamp, a high-throughput system for aging research in C. elegans, showing it can estimate lifespan and healthspan through collective activity monitoring.

This study shows that lower leaf nitrogen content in tomato plants delays photosynthetic induction when transitioning from low to high light, primarily due to reduced mesophyll conductance.

The paper updates RNA helix thermodynamic parameters by incorporating sequence-dependent terminal penalties, improving prediction accuracy for helix stability.

This study identifies Phostensin as a regulator of integrin activation in lymphocytes by stabilizing the MIT complex through Rap1 dephosphorylation, leading to lymphoid organ population and T cell-mediated colitis.

This study investigates the role of Rap1-talin1 interactions and RIAM in integrin activation in CD4+ T cells, showing that RIAM can substitute for Rap1 binding in some contexts.

This study develops an mRNA-LNP vaccine (STI-7264) and a lymphatic delivery device (MuVaxx) that enhance immune responses against SARS-CoV-2 with reduced dosing.

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

The paper analyzes single-cell data from CAR T infusion products to identify factors associated with CD19-positive relapse in ALL patients.

This study identifies TNFAIP8 as a phosphoinositide-binding regulator of Rho GTPases that promotes cancer cell migration by linking inflammation to phosphoinositide signaling.

This study examines factors driving radiating diversification in Saussurea using Miocene to present data, finding increased diversification rates linked to climate fluctuations and adaptive traits.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This paper investigates ion permeation mechanisms in AMPA-type glutamate receptors using molecular dynamics simulations and electrophysiology, finding a simple selectivity filter that allows non-selective cation permeation.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study shows that high-dose sodium butyrate causes reversible metabolic paralysis by inducing transient mitochondrial reprogramming in the brain, specifically through ANT protein activation and proton leak.

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

This study identifies a leucine-derived fatty acid and glycosphingolipid that mediate amino acid sensing by mTORC1 in C. elegans, regulating development through protein translation and ribosomal biogenesis.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

This paper develops a de novo lipid labeling method using a single fluorescent probe to analyze subcellular distribution and trafficking of major lipid species in live cells, revealing new biological functions of lipid metabolic enzymes.