H. Wu

This paper presents a total chemical synthesis of the TREM2 ectodomain, demonstrating its functional effects on microglial cells and highlighting the importance of glycosylation for thermal stability.

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

The paper investigates silica-induced pulmonary fibrosis in mice, finding that silica triggers osteoclast-like differentiation of macrophages and monocytes, contributing to lung injury and fibrosis.

The paper shows that low gut microbial diversity worsens estrogen-driven pulmonary fibrosis in female ILD by linking gut dysbiosis, estrogen, and inflammatory pathways.

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.

This paper presents the cryoEM structure of full-length αIIbβ3 integrin, revealing its activation states and providing insights into its role in platelet function and potential therapeutic targeting.

This paper develops a non-viral system for efficient genome engineering using circular single-stranded DNA (cssDNA) donors, achieving high knock-in efficiency and improved safety compared to viral vectors.

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

The paper uses molecular dynamics and AI to show eukaryotic histones can form stable homodimers, with disordered tails favoring heterotypic dimers.

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

The paper identifies and characterizes a novel hypovirus and its satellite-like dsRNA from Pestalotiopsis fici, showing it lacks a poly(A) tail and ORF, and negatively regulates the helper virus.

This study shows HDAC7 regulates CD8+ T cell function by controlling survival, calcium homeostasis, and memory responses, impacting anti-viral and anti-tumor immunity in mice.

This study identifies sialidases and fucosidases in Akkermansia muciniphila that degrade mucin glycans and enable nutrient sharing with gut bacteria.

This study optimizes primer sets for detecting Influenza A viruses using RRT-PCR, finding that HA primers are most sensitive for field sample detection.

This paper reports cryo-EM structures of the IgM BCR and its Fab-deleted form, revealing an asymmetric arrangement and novel structural principles of BCR assembly.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study compares three transcytotic pathways for drug delivery to brain metastases of breast cancer and finds that albumin shows optimal distribution and uses a novel clathrin-independent endocytosis mechanism.

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

This paper demonstrates baseline IMS resolution of intact isomeric proteoforms, specifically acetylated H4 histones, using trapped IMS on a Bruker TIMS/ToF platform.

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

The paper uses CRISPR-based gene deletion to study Cre1's role in carbon catabolite repression in Coprinopsis cinerea, revealing its regulation of plant biomass degradation genes.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

This study uses single-cell RNA sequencing to analyze shrimp hemocytes, revealing evolutionary parallels between invertebrate and vertebrate myeloid cells.

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

This study shows Piezo1 and 2 regulate centrosome integrity by modulating Ca2+ levels through mechanotransduction of cell intrinsic forces.