H. Wu

The paper introduces NeoRdRp, a dataset of RNA-dependent RNA polymerase (RdRp) HMM profiles for identifying RNA viruses from metatranscriptomic data, showing improved detection compared to existing methods.

The paper explores fusion protein strategies to improve cryo-EM structure determination of GPCRs without signaling proteins, achieving resolutions of 3.4 and 3.7 Å for two receptors.

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

This paper identifies 921 conserved genes involved in fruiting body morphogenesis across Agaricomycetes fungi and proposes functional hypotheses for many of them.

This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study shows Nf1 loss in myogenic progenitors causes quiescence and metabolic reprogramming, leading to muscle weakness in NF1 patients.

This study characterizes the E34 phage tailspike protein, identifies key residues for LPS binding and hydrolysis, and shows its potential as a therapeutic against Salmonella infection.

This study identifies full-length NLRP3 as a membrane-localized oligomeric cage that senses stimuli and activates the inflammasome, distinct from other monomeric inflammasome sensors.

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

This study shows that exosomal miR-140-3p from diabetic BMSCs promotes bone restoration in diabetic rats by enhancing osteogenesis and inhibiting the plexin B1 signaling pathway.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study evaluates the neutralization potency of SAB-185, a fully human antibody immunoglobulin from transchromosomic bovines, against multiple SARS-CoV-2 variants using pseudovirus assays.

This study evaluates the neutralizing capacity and protective efficacy of human polyclonal IgG against SARS-CoV-2 variants in vitro and in a transgenic hamster model.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This paper describes a fully human immunoglobulin from transchromosomic bovines that neutralizes SARS-CoV-2 variants, including those with mutations like E484K and N501Y.

The paper simulates freely-diffusing single-molecule FRET data with conformational dynamics using Langevin dynamics to test analysis techniques for flexible proteins.

The paper develops algebraic solutions to improve the accuracy of rotational correlation time estimation using TRACT experiments by addressing limitations in existing methods.

This study reveals how DPP9 regulates CARD8 by forming a ternary complex and shows that DPP9 inhibitors activate CARD8 inflammasomes through two distinct mechanisms.

This study uses liver electrical impedance tomography to detect fatty infiltration in obese individuals, finding a negative correlation between EIT conductivity and MRI-measured fat fraction.

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.