H. Yang

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Dual role of Vascular Endothelial Growth Factor-C (VEGF-C) in post-stroke recovery

This study shows that VEGF-C promotes brain infarcts after stroke, while blocking VEGFR-3 improves outcomes, highlighting a dual role for VEGF-C in stroke recovery.

A conserved ion channel function of STING mediates non-canonical autophagy and cell death

This study identifies STING's ion channel function as critical for non-canonical autophagy and cell death via vesicle de-acidification.

Targeted lipid A modification of Shigella vaccine strains reduced endotoxicity without compromising immunogenicity or invasiveness

This study modifies Shigella lipid A to reduce endotoxicity while maintaining immunogenicity and invasiveness.

Endothelial TMEM16F lipid scramblase regulates angiogenesis

This study identifies TMEM16F as a regulator of angiogenesis through intracellular signaling, showing impaired retinal angiogenesis in TMEM16F-deficient mice and altered VE-cadherin and Src kinase activity in human endothelial cells.

Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring

This study shows maternal and embryonic osteocalcin work together to maintain homeostasis in offspring by affecting insulin secretion, glucose metabolism, and steroidogenesis.

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma

This study shows that CDDO-Methyl Ester reduces BRAF inhibitor resistance in melanoma by altering the tumor microenvironment and myeloid cell composition.

Niclosamide potentiates TMEM16A and induces vasoconstriction

This study shows niclosamide potentiates TMEM16A and induces vasoconstriction, challenging its use as a TMEM16A inhibitor for asthma and COPD.

Increasing Chemotherapeutic Efficacy Using pH Modulating and Doxorubicin Releasing Injectable Chitosan-Polyethylene Glycol Hydrogels

This paper develops a hydrogel that delivers doxorubicin and sodium bicarbonate to neutralize tumor acidity and enhance chemotherapy efficacy.

Structural determination of Rickettsia lipid A without chemical extraction confirms shorter acyl chains in later-evolving Spotted Fever Group pathogens

Structural insights into dual-antagonize mechanism of AB928 on adenosine A2 receptors

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis

The paper shows that inhibiting RAR signaling in PTECs during AKI increases Kim-1 expression, which enhances efferocytosis and protects against injury.

KLIPP - a precision CRISPR approach to target structural variant junctions in cancer

KLIPP uses CRISPR/Cas9 to target cancer-specific structural variant junctions, inducing DNA breaks and cell death in tumor cells with high specificity.

A murine commensal protozoan relieves Clostridium difficile infection through regulating the arginine metabolism and the host intestinal immune response

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

VERY LONG-CHAIN ACYL-CoA SYNTHETASE-3 (ACSVL3) PROMOTES THE MALIGNANT GROWTH BEHAVIOR OF U87 GLIOMA CELLS VIA CHANGES IN CELL CYCLE WITHOUT AFFECTING APOPTOSIS

This study shows that reducing ACSVL3 expression in U87 glioma cells slows their growth and tumor formation in mice by altering the cell cycle without affecting apoptosis.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

CUR(E)ating a New Approach to Study Fungal Effectors and Enhance Undergraduate Education through Authentic Research

This paper describes a CURE course focused on fungal effectors that enhances undergraduate education through authentic research and real-world problem-solving.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Deep learning permits imaging of multiple structures with the same fluorophores

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

Does the territorial behaviour of the Amur tiger affect the accuracy of occupancy estimation?

This study develops a modified occupancy model to distinguish true-presence from pseudo-presence in Amur tigers, improving occupancy estimation accuracy by accounting for territorial behavior.

Trophoblast organoids with physiological polarity model placental structure and function

The paper develops trophoblast organoids with physiological polarity to model placental structure and function, showing improved hormone secretion and syncytium size.

A pilot study of stable isotope fractionation in Bombyx mori rearing

This study measures stable isotope fractionation in Bombyx mori strains across life stages to trace isotope movement and understand fractionation patterns.

The structural basis of itch receptor MRGPRX1 activation

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

An engineered xCas12i with high activity, high specificity and broad PAM range

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

SARS-CoV-2 infected cells sprout actin-rich filopodia that facilitate viral invasion

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.