H. Zhang

This study shows that lipid availability is critical for metabolic maturation of human pluripotent stem cell-derived cardiomyocytes, with exogenous lipid supplementation improving mitochondrial function and fatty acid oxidation.

This study investigates the co-production of tet(X6) and mcr-1 resistance genes on a single plasmid in E. coli, revealing their independent mechanisms of antibiotic resistance and the implications for antimicrobial resistance spread.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

This study identifies how type I interferon remodels lysosomes to enhance Salmonella virulence and pathogenesis in intestinal epithelial cells.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

This study compares the effects of different fertilization patterns on soil microbial diversity, structure, and function in greenhouse vegetable production systems, finding that higher manure substitution improves soil quality and microbial activity.

The paper compares three glycoproteomic methods for analyzing N-linked glycosites in CHO cells treated with 1,3,4-O-Bu3ManNAc, finding that NGAG identifies more glycosites than SPEG and HILIC.

The paper identifies liver-related signaling pathways activated during RPE EMT using proteomic and phosphoproteomic analysis, suggesting potential therapeutic targets for visual diseases.

This study shows that ER reorganization and CD58 retention by HCMV UL148 are independent functions, as mutations affecting one do not impact the other.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study shows anacardic acid reduces PE-induced cardiac hypertrophy by inhibiting JNK signaling and HAT-mediated histone acetylation in mice.

The paper describes a new small-bodied troodontid dinosaur from the Upper Cretaceous of Inner Mongolia and confirms its phylogenetic position through analysis.

The paper profiles miRNAs and uses degradome sequencing to study their role in CMS regulation during anther development in pepper, identifying differentially expressed miRNAs and their target transcripts.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

This study investigates how peptidoglycan-deficient spherical spores of Myxococcus xanthus germinate into rod-shaped cells by elucidating the role of MglB, MglA, MreB, and molecular motors in de novo PG synthesis and shape establishment.

The study shows that the C. difficile strain 630Δerm has a mutation in PerR that causes oxidative stress response under anaerobic conditions, challenging its use as a model strain.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This study determines the structure of hDGAT1 with a substrate, revealing its homodimeric organization and substrate-binding sites.

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

This study uses deep residual neural networks to infer four-taxon phylogenies, outperforming existing methods under substitution heterogeneities.

This study develops nanotube-based delivery of siRNA to plant cells, achieving efficient gene knockdown by overcoming cell wall barriers and nuclease degradation.

This study identifies a link between geometric features of melanoma aggregates and reprogramming to stem cell-like initiating cells through histone modifications.

The DNA-guided Argonaute protein TtAgo in Thermus thermophilus aids in separating daughter chromosomes after DNA replication.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.