H. Zhang

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

The paper identifies four σ28-dependent sRNAs regulating flagella biosynthesis in E. coli, showing varied effects on flagellin levels, flagella number, and motility.

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper introduces a mass spectrometry platform combining acoustic droplet ejection, open-port interface, and electrospray ionization for high-speed, label-free analysis across multiple applications.

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

This paper introduces IsoNet, a deep learning tool that reduces resolution anisotropy in cryoET data, improving structural interpretability without sub-tomogram averaging.

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

The paper identifies ProXs, proteins capable of forming membraneless organelles in plants, and shows their conservation across species.

This study quantifies how Vibrio cholerae lands on surfaces in viscoelastic environments using MSHA pili and flagellum, showing pili act as brakes and anchors during landing.

The paper identifies 41 viral clusters in groundwater plasmidomes, links them to bacterial hosts, and detects novel phage genera and host-specific genes.

This study meta-analyzes DNA metabarcoding and traditional methods for aquatic community assessment, finding congruence for fish but complementarity for microorganisms and macroinvertebrates.

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

This study shows that amitosis in Tetrahymena provides evolutionary benefits similar to sex, enabling long-term success of asexual lineages by reducing mutation load and accelerating adaptation.

This study identifies two types of scales in an Early Cretaceous bird fossil, suggesting all four modern bird scale types existed by that time.

This study investigates H3K27 demethylation during Arabidopsis germination, showing REF6 establishes a transcriptionally permissive state by counteracting PRC2 activity.

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

This study identifies a novel constitutive MLS resistance in S. haemolyticus and shows that ErmC deletion causes resistance while continuous ErmC expression imposes a growth cost.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

The paper identifies an epigenomic shift in the amygdala of virgin female mice exposed to pups, associated with the transition to maternal behaviors.

This paper proposes a method to measure heart rate remotely using a surveillance camera, achieving 95.8% accuracy at 4.5 meters and 90% at 5.0 meters under varying light conditions.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.