J. Li

This study shows that endothelial SIRT3 regulates metabolic shifts and fibrosis in diabetic kidneys by controlling EndMT and metabolic reprogramming.

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

This study uses micro-XRF to analyze the holotype of Jianianhualong tengi, revealing elemental patterns linked to fossil structure and taphonomy.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

The paper shows yeast cells use genetically controlled mtDNA editing to prevent ROS damage by shutting down oxidative phosphorylation.

AMPGAN v2 generates novel antimicrobial peptides with higher precision and selectivity for resistant targets using a bidirectional conditional generative adversarial network.

This paper uses synchrotron SAXS to investigate the structural behavior of oat protein isolate in aqueous solutions, revealing disk-shaped structures at low concentrations and rodlike aggregates at higher concentrations.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

This study identifies non-invasive plasma glycomic and metabolic biomarkers that predict viral rebound after HIV treatment interruption with high accuracy.

The paper investigates the mechanical anisotropy of ZIKV xrRNA1 using single-molecule nanopore sensing and molecular dynamics simulations, revealing its dependence on Mg2+ and tertiary interactions.

This study identifies LINE-1 retrotransposons as mediators of horizontal gene transfer into poxviruses, showing their role in gene integration and viral adaptation.

The paper constructs and validates a prognostic signature for prostate cancer using ferroptosis-related genes, showing its association with clinical outcomes and therapeutic response.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

This paper introduces PIC-IT, a photoconversion-based technique to isolate spatially distinct tumor cells, revealing phenotypic heterogeneity and NF-κB/AP-1 signaling enrichment in disseminated tumor cells.

This paper develops a generative model to design antimicrobial peptides with high activity and selectivity, validated through molecular simulations and experimental testing.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This paper improves automated Gleason grading by using image-based patch selection to enhance segmentation accuracy in histopathological slides.

This study establishes an in vitro system using honey bee pupal cells to study DWV infection and replication, identifying key factors and potential inhibitors.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This study identifies two monoclonal antibodies that bind SARS-CoV-2 spike protein RBM and inhibit GM-CSF induction in immune cells.

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

This study identifies BonA as an outer membrane protein in Acinetobacter baumannii that forms a transient decamer, supports outer envelope function, and is involved in cell division and motility.