J. Singh

PhenoImage: an open-source GUI for plant image analysis

PhenoImage is an open-source GUI tool for analyzing high-throughput plant phenotyping images, designed for users without programming skills.

Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

Rules of Contact Inhibition of Locomotion for Cells on Suspended Nanofibers

This study investigates contact inhibition of locomotion (CIL) on suspended nanofibers, revealing distinct behaviors compared to 2D substrates and showing how fiber geometry and cell division influence cell-cell interactions.

Physiological and molecular responses to combinatorial iron and phosphate deficiencies in hexaploid wheat seedlings

This study examines how hexaploid wheat responds to iron and phosphate deficiencies, finding that combined deficiencies rescue root growth inhibition and trigger specific gene and metabolite changes.

A nitrogen source-regulated microprotein confers an alternative mechanism of G1/S transcriptional activation in budding yeast

The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.

Super-resolved polarisation-enhanced second harmonic generation for direct imaging of nanoscale changes in collagen architecture

This paper introduces a super-resolution SHG technique that achieves nanoscale imaging of collagen architecture without fluorescent labels, revealing previously unobservable structural changes.

The Arabidopsis gene RGO mediates cytokinin responses and increases seed yield

RGO, a novel gene from Arabidopsis, is essential for plant development, mediates CK signaling and increases seed yield in Arabidopsis and rapeseed when overexpressed.

New North American isolates of Venturia inaequalis can overcome apple scab resistance of Malus floribunda 821

The paper identifies new Venturia inaequalis isolates in North America that can overcome Rvi6 resistance in Malus floribunda 821, suggesting local evolution of virulence.

Bulked segregant RNA-Seq reveals differential genes and non-synonymous genetic variants linked to sucrose accumulation in sugarcane

This study uses bulged segregant RNA-Seq to identify non-synonymous variants and differentially expressed genes linked to sucrose accumulation in sugarcane.

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.

Integrative analysis of hexaploid wheat roots identifies signature components during iron starvation

This study identifies gene and metabolic signatures in hexaploid wheat roots under iron starvation, revealing key transporters and metabolites involved in Fe acquisition and response.

Reaction mechanisms of Pol IV, RDR2 and DCL3 drive RNA channeling in the siRNA-directed DNA methylation pathway

Syndecan-1 facilitates breast cancer metastasis to the brain

This study shows that syndecan-1 promotes breast cancer metastasis to the brain by enhancing cell migration across the blood-brain barrier and altering cytokine secretion.