J. Wang

The study analyzes viral diversity in individual bats to assess co-infection, spillover, and zoonotic risk of potential viruses.

This study infects human iPSC-derived CNS and PNS neurons with SARS-CoV-2 and finds that PNS neurons experience more severe neurodegeneration linked to innate immune activation.

The paper shows Runx factors regulate T-cell and innate lymphoid programs through dynamic binding and gene network interactions during early development.

The paper uses amplicon sequencing to analyze parasite strain diversity in mothers and infants infected with Trypanosoma cruzi, finding multiple strains in some individuals and increased diversity in infants post-birth.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

This study identifies NlpE as an OmpA-associated sensor that activates the Cpx envelope stress response in surface-adhered Gram-negative bacteria by transducing signals from OmpA overexpression.

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

The paper investigates the role of TPLATE complex-dependent endocytosis in regulating CLAVATA1 signaling in Arabidopsis shoot apical meristem maintenance.

The paper introduces a kinase inhibitor pulldown assay (KiP) combined with PRM for clinical proteomics, improving kinase quantification in cancer samples.

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

The paper analyzes NIH Research Project Grant costs from 1998 to 2021, finding stable real costs post-2003 despite nominal increases and higher proportion of solicited projects.

This paper introduces a second-generation dual-channel VIS-OCT system that achieves wide-field, full-range, and shot-noise limited retinal imaging with improved depth resolution and SNR.

This paper introduces a hybrid method combining a physical model with deep learning to improve structured illumination microscopy, achieving better artifact suppression and resolution in low SNR images.

The paper identifies a protein complex that promotes early endosome bud biogenesis through lipid transport at Golgi-endosome contacts.

This study shows that inhibiting MAO-A in cardiomyocytes reduces arrhythmias by improving diastolic calcium control following catecholamine stress.

The paper develops a computational model to study microtubule-cytoplasm interaction in plant cells, showing microtubules align orthogonally to cell elongation and matching experimental results.

The paper introduces an automated high-throughput system for plant imaging and phenotyping, demonstrating its ability to analyze large-scale plant-microbe interactions across diverse nutrient environments.

This study shows Bordetella spp. block eosinophil recruitment to prevent iBALT formation, which suppresses immune responses and promotes bacterial persistence.

The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.