J. Zhang

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

The paper predicts key dynamic interacting proteins in multiple cancers and identifies their functional characteristics and network roles.

This study shows SARS-CoV-2 Spike protein damages endothelial cells by reducing ACE2 expression and impairing mitochondrial function, leading to vascular inflammation.

This study examines how different light spectra affect nitrogen assimilation and content in Quercus variabilis seedlings under nitrogen pulses.

The paper shows that the W344R mutation in Kv7.2 channels causes co-translational misfolding, impairing CaM binding and leading to non-functional ion channels.

This paper shows GANs can generate realistic western blot images that fool researchers, highlighting the need for better detection methods and image verification protocols.

This study shows that ssc-miR-132 reduces inflammation and apoptosis in IPEC-J2 cells caused by C. perfringens beta2 toxin by targeting DACH1.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

This study shows that insulin resistance in skeletal muscle protects the heart from dysfunction in diet-induced obesity, despite worsening obesity and metabolic syndrome.

The paper identifies a plant lipocalin, TIL, that is required for retinal-mediated de novo root organogenesis in Arabidopsis.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

This study shows that moderate treadmill running maintains tendon homeostasis by promoting TSC differentiation into tenocytes, while intensive treadmill running induces tendinopathy by causing TSCs to differentiate into non-tenocyte cells.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

This study uses electrochemical methods to analyze extracellular electron transfer in E. coli, showing enhanced current production with vitamin K3 and partial direct electron transfer in biofilms.

This study shows that cannabidiol (CBD) reduces pulmonary arterial hypertension by improving mitochondrial function and reducing oxidative stress in vascular smooth muscle cells.

This study establishes a mouse model of renal cell carcinoma showing that 9p21 loss drives aggressive tumor evolution with chromosomal instability and metastasis.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

This paper develops a de novo lipid labeling method using a single fluorescent probe to analyze subcellular distribution and trafficking of major lipid species in live cells, revealing new biological functions of lipid metabolic enzymes.

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

Introgression of the 1Ay21* HMW-GS increases wheat grain protein content and improves bread-making quality by reshaping the grain proteome network.