L. Wang

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

The paper introduces a bioreactor that uses electric fields to guide cell migration in real-time, demonstrating precise 2D collective migration maneuvers in renal epithelia and skin keratinocytes.

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

This study shows nilotinib activates endothelial TLR4, promoting atherosclerosis, and suggests TLR4 inhibition could mitigate this effect.

This study investigates how the feeding behavior of Monochamus alternatus affects the departure of pine wood nematodes, finding no significant difference but linking increased motility and oxidative phosphorylation to nematode departure.

This study identifies Cqs2 as the critical determinant for orchestrating the unisexual cycle in Cryptococcus neoformans without requiring the sex-determination program.

The paper identifies an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies, showing its role in stress tolerance and 3D growth.

The paper shows that weak, liquid-like interactions between Eps15 and Fcho1 enable efficient endocytosis by promoting dynamic protein assembly and preventing stalling of vesicle budding.

The paper identifies CsHscB from Clonorchis sinensis as a TLR2 agonist that modulates macrophage activation and IL-10 production through TLR2-dependent mechanisms.

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study shows that the mouse superior colliculus is causally involved in visual perceptual decision-making by demonstrating that its inhibition impairs detection of orientation changes in the contralateral visual field.

This study examines how drought and chilling stresses individually and together affect maize growth and oxidative metabolism, finding that combined stress is more harmful than either alone, with hybrids better tolerating stress than inbreds.

This paper develops a framework for glomerulus segmentation in kidney histopathology images using Faster R-CNN and U-Net with weakly supervised training.

This paper shows that using multiple low doses of drugs targeting different components of a signaling pathway can effectively treat EGFR inhibitor-resistant NSCLC without resistance development.

This study characterizes the mutational and transcriptomic landscapes of a rare prostate basal cell carcinoma using single-cell sequencing, revealing unique gene expression and regulatory patterns.

This study examines how high temperatures affect grape berry metabolism at different developmental stages using proteomic and metabolomic analyses, identifying key proteins and metabolic changes linked to heat stress.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This study shows that Vps29 is essential for retromer function in aging Drosophila brains, affecting synaptic transmission and endolysosomal function through interactions with Rab7 and TBC1D5.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

This study shows that proteolytic cleavage, not receptor binding, is the main barrier for two MERS-like bat coronaviruses to infect human cells, and that trypsin treatment can overcome this barrier.

The paper identifies a unique adipocyte population in bone marrow, MERAs, that regulate bone and vessel homeostasis through single-cell transcriptomics in mice.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

This study compares cold resistance in two discus fish species using antioxidant indexes, finding interspecific variation linked to environmental adaptation.

This paper identifies Bacillus subtilis WL-2 and its IturinA lipopeptides as effective inhibitors of Phytophthora infestans mycelium growth through mechanisms involving cell membrane damage, oxidative stress, and mitochondrial dysfunction.

This study shows that MCL-1 inhibition by BH3 mimetics disrupts mitochondrial dynamics and function in iPSC-derived cardiomyocytes, suggesting a non-apoptotic role for MCL-1 in cardiac health.

The paper examines the roles of three wheat glutamine synthetase isozymes in nitrogen assimilation and translocation, showing distinct functions and synergistic effects.

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.