L. Zhang

This study determines the crystal structure of Senecavirus A 3C protease at 1.9 Å resolution, revealing structural differences in the binding groove that may influence cleavage efficiency.

The paper quantifies species-specific CpG distribution patterns across genomic scales and shows their correlation with chromatin structure in mammals and avians.

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

The paper determines the X-ray structure of SARS-CoV-2 main protease and uses it to design alpha-ketoamide inhibitors with improved pharmacokinetic properties.

This study shows infrared heater warming reduces dew formation by 41.6%-91.1% and shortens its duration by 32.1 days in alpine grasslands.

This study identifies alpha-ketoamides as broad-spectrum inhibitors effective against coronavirus and enterovirus proteases, with compounds showing low-micromolar activity in cell cultures.

This study shows butyrate promotes virus infection by repressing interferon stimulated genes without disrupting IFN signaling.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study identifies PvdS as a regulator of the type I-F CRISPR-Cas system in P. aeruginosa under iron-depleted conditions, enhancing horizontal gene transfer interference.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

This paper solves the crystal structure of the giant panda MHC class I complex, revealing unique features of viral peptide presentation in the bear family and providing insights for vaccine design.

The paper examines how 3D chromatin structure and DNA methylation change in cancer, showing increased segregation of chromatin domains and methylation differences that correlate with transcriptional changes.

The paper identifies CK2 interacting proteins in M. oryzae and shows CK2 correlates with phosphatases and disaggregases, suggesting a role in protein aggregation and RNA/DNA binding.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper presents the cryo-EM structure of AftD from M. abscessus and shows its interaction with ACP, revealing potential regulatory mechanisms.

This study shows that low basal expression and slow induction of IFITM3 in immune cells increases their susceptibility to influenza A virus infection.

This study examines the relationship between visual impairment, spectacle use, and academic performance in junior high school students in western China, finding that spectacle ownership is linked to better test performance.

This paper identifies functional noncoding SNPs and their molecular mechanisms for 19 autoimmune diseases using multi-omics data and prioritizes drug targets.

This study identifies three phases of inflammation after spinal cord injury in rats and shows ongoing inflammatory damage and a link between astrogliosis and reduced inflammation severity.

This study shows that reducing temperature induces widespread alternative splicing in CHO cells, with many events occurring in genes not detected by standard expression analysis.

This study expands the long non-coding RNA (lncRNA) transcriptome of Chinese hamster ovary (CHO) cells using RNASeq, doubling annotated lncRNA transcripts and identifying 1,000 new antisense lncRNAs.

The paper evaluates three 16S rRNA sequencing protocols for vaginal microbiome analysis and identifies biases in species abundance estimation, proposing an optimized protocol to improve accuracy.

This study shows Bax and Bak control survival and reduce early ER stress in β-cells under glucolipotoxic stress through non-apoptotic and apoptotic mechanisms.

This study identifies the DNA specificity and structural basis of BRG1's composite domain using SELEX-seq, NMR, and modeling, showing how cancer mutations alter DNA binding.

This study identifies and characterizes the kisspeptin system in the sea cucumber Apostichopus japonicus, revealing its existence and function in a non-chordate species.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.