N. Wang

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

This study shows citrus Huanglongbing is an immune-mediated disease caused by CLas, where ROS-induced cell death in phloem tissues can be mitigated by antioxidants and gibberellin, reducing disease symptoms.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

The paper identifies natural interploidy hybridization among wild chrysanthemum species involved in the origin of cultivated chrysanthemums, revealing patterns influenced by reproductive isolation and human activity.

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

This study uses edge-based analysis to examine phylogenomic conflicts in avian evolution, revealing gene-specific biases and data type effects that impact resolution of contentious nodes.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study identifies EXOSC1 as an endogenous source of mutation in KIRC that promotes DNA damage and sensitizes cells to PARP inhibitors.

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

This study combines computational and experimental methods to evaluate drug potency, efficacy, and safety for targeting membrane proteins, using SERCA2a as a model.

This study analyzes DNA methylation across 11,117 samples from 176 species to identify modules related to traits like age, lifespan, and phylogeny, revealing epigenetic patterns across evolution and aging.

The paper identifies prevalent, protective, and convergent IgG antibodies targeting non-RBD epitopes of SARS-CoV-2 spike protein in convalescent plasma.

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

The paper uses molecular and morphological data to clarify species boundaries in Betula section Costatae, identifying a new species, Betula buggsii, within the group.

The paper investigates how microtissue geometry and cell-generated forces influence liver progenitor cell differentiation patterns in 3D by combining microfabrication, imaging, and mechanical modeling.

The paper tests hypotheses about genetic diversity patterns in Betula albosinensis, finding support for the central-marginal hypothesis and the role of multiple glacial refugia.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study resolves the phylogeny and polyploid parentage of birch trees using genome-wide sequence data, revealing two subgenera and complex reticulate origins of polyploid taxa.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This paper shows how Begomovirus uses a phosphatase to suppress plant immunity, enhancing virus transmission by herbivore vectors.

This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.