N. Wang

Identification and Characterization of a Novel Major Facilitator Superfamily (MFS) Efflux Pump SA09310 Mediating Tetracycline Resistance in Staphylococcus aureus

This study identifies and characterizes SA09310 as a novel tetracycline resistance efflux pump in Staphylococcus aureus, showing it mediates drug resistance through H+-dependent extrusion.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

Machine learning prediction of cancer cell metabolism from autofluorescence lifetime images

This paper uses machine learning on autofluorescence lifetime images to predict metabolic pathway usage in cancer cells, achieving 95% accuracy in distinguishing glycolytic and oxidative metabolism.

Membrane curvature-generating proteins crucial for autophagosome formation

This study identifies REEP1 proteins as essential for autophagosome formation by stabilizing the high curvature of the phagophore rim.

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

Genomic data support Betula halophila and Betula microphylla as one species and reveal unidirectional introgression from Betula pendula to Betula microphylla

The paper uses RADseq to show Betula halophila and Betula microphylla are one species, with introgression from B. pendula to B. microphylla, and identifies salt-tolerance genes in introgressed regions.

A nearly 30-years living collection from the Royal Botanic Garden Edinburgh is a new species: a case study of Betula mcallisterii sp. nov. (sect. Acuminatae, Betulaceae) and its little hybridization with Betula luminifera

The paper describes a new birch species, Betula mcallisterii, identified through morphology, DNA sequencing, and flow cytometry, with minimal hybridization with its close relative.

Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

Effective root responses to salinity stress include maintained cell expansion and carbon allocation

This study compares root growth responses of the halophyte Schrenkiella parvula and Arabidopsis thaliana under salt stress, identifying gene regulatory differences and physiological adaptations that enable salt tolerance.

Genomic signals of local adaptation and hybridization in Asian white birch

This study analyzes genomic diversity in Asian white birch to identify signals of adaptation and hybridization, finding 7,609 SNPs associated with environmental variables and highlighting climate change risks.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

Hypereosinophilia causes progressive cardiac pathologies in mice

This study shows that hypereosinophilia in mice leads to cardiac inflammation and impaired cardiomyocyte contractility, contributing to heart dysfunction.

The molecular mechanism and physiological role of silent nociceptor activation

This study identifies TMEM100 as a key regulator of silent nociceptor activation during inflammation and shows its role in inducing remote pain hypersensitivity.

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

Formulation of substrates with agricultural and forestry wastes for Camellia oleifera Abel seedling cultivation

The paper evaluates five compost-based substrates for Camellia oleifera seedling cultivation, finding that a specific combination yields optimal growth and survival rates.

Systematic Characterization of Double Emulsion Droplets for Biological Applications

This paper systematically characterizes double emulsion droplets to predict their size and stability based on flow rates and buffer properties, enabling better design of bioassays.

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Divergent age-related methylation patterns in long and short-lived mammals

The paper identifies CpGs with divergent age-related methylation patterns in long and short-lived mammals and develops epigenetic clocks based on these CpGs.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

Highly efficient generation of canker resistant sweet orange enabled by an improved CRISPR/Cas9 system

This paper improves a CRISPR/Cas9 system for sweet orange to generate biallelic mutations with high efficiency, enabling the creation of canker-resistant citrus varieties.

Base editors for citrus gene editing

This paper adapts base editors for precise gene editing in citrus, achieving transgene-free resistance to pathogens and herbicides.

Metabolomic and transcriptomic analyses reveal the effects of grafting on anthocyanin synthesis in grapevine

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.