Q. Zhao

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

This study identifies distinct immune ecosystems in true and de novo HBV-related HCC recurrences using single-cell and bulk RNA-sequencing, revealing differences in T cell phenotypes and immune interactions that may inform immunotherapy strategies.

HSP90.6 regulates maize grain filling by affecting 26S proteasome-mediated nitrogen recycling and GF14-6-mediated carbon metabolism.

This study uses scRNA-seq to identify metabolic reprogramming in human colonic immune cells across locations and ulcerative colitis states, linking metabolism to immune function and treatment resistance.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

This study uses CT scans to analyze the dental systems of three Jurassic ceratopsians, revealing tooth replacement patterns and dietary strategies that inform their evolution.

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

The paper develops a method to deliver mRNA to multiple virus-specific T cells using light-induced ligand exchange of MHC class I antigen-presenting nanoparticles, achieving ~50% transfection in vivo.

This study shows that hematopoietic SLC37A2 deficiency accelerates atherosclerosis in LDL receptor-deficient mice by impairing anti-inflammatory responses and IL-10 production.

The paper develops a new alkynyl-enrichable crosslinker for in-vivo crosslinking analysis, identifying 6820 non-redundant crosslinks in human cells with a 1% FDR.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

The paper introduces an enhanced sampling method for protein-ligand binding with induced fit, validated on ADPr and MacroD1/MacroD2 complexes, showing accurate free energy predictions and structural changes.

This paper develops a chemiluminescence immunoassay for detecting ASFV antibodies in serum, showing high specificity, sensitivity, and consistency with a commercial kit.

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

This paper compares deep learning and machine learning approaches for decoding motor intent from nerve signals, finding that deep learning offers better accuracy with large data while machine learning is more efficient with smaller datasets.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

This study identifies the PELOTA-HBS1 complex's role in mRNA translation surveillance and PDK1-mediated plant growth by rescuing a pdk1 mutant in Arabidopsis.

This study uses proteomics to identify complement cascade pathway changes in gastric signet ring cell carcinoma tissues compared to adjacent regions and adenocarcinomas.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.