R. Zhang

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.

The paper reports the crystal structure of the human NgBR/DHDDS complex, revealing how it stabilizes the active site and is regulated by phospholipids in protein glycosylation.

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

The paper identifies HaRxL21, an oomycete effector, and shows it interacts with TPL to suppress plant immunity and promote pathogen susceptibility.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

This study identifies MBOAT7-driven phosphatidylinositol remodeling as a driver of clear cell renal cell carcinoma progression and highlights MBOAT7 as a potential therapeutic target.

This study identifies sPML-II as the isoform that inhibits PRV infection by suppressing viral gene transcription through its 7b region.

This study shows MBOAT7 regulates glycolysis in ccRCC by reducing glycolytic gene expression, intermediates, and respiration, and improving survival in xenograft models.

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

The paper identifies and characterizes three shared enzymes in mitochondrial and plastidial fatty acid synthase systems and shows their dual localization and functional consequences.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.

This study found that a significant proportion of E. coli isolates from ready-to-eat lettuce in Northern California carry beta-lactam resistance genes, posing a potential risk for human infections.

This study investigates how Chlamydomonas sp. UWO241 maintains high cyclic electron flow and rewired metabolism under high salinity stress.

This study shows that rabies virus glycoprotein suppresses gastric cancer migration by inhibiting the 7-nAChR-MEK/ERK-EMT pathway.

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This paper introduces two 2D HETCOR NMR pulse sequences to enhance sensitivity for rigid and mobile components in heterogeneous systems by leveraging different MAS conditions and polarization transfer mechanisms.

This study shows that Dram1 deficiency in zebrafish increases susceptibility to Mycobacterium marinum infection by impairing phagosome maturation and inducing pyroptotic cell death in macrophages.

This paper identifies carbon starvation stress as a trigger for the PprB regulon in Pseudomonas aeruginosa, revealing its role in enhancing biofilm adhesion through BapA and CupE.