S. Jain

The paper shows that aged microbiota causes leaky gut and inflammation by reducing butyrate and FFAR2/3, which weakens mucin barriers.

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

This study shows that dichloroacetate improves energy balance and feeding behavior in sepsis by reversing metabolic dysfunctions and glycine deficiency.

The paper shows that CD4-targeted bacteriophage T4 nanoparticles reactivate HIV-1 latency in CD4+ T-cells without global activation or cytokine storm.

The paper identifies multiple structural conformations of the SARS-CoV-2 frameshifting RNA element and their potential roles in viral replication and therapeutic targeting.

The paper identifies a genetic shift in an HIV-1 transmitted/founder virus that leads to broader antibody responses by altering the V2 domain structure.

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

This study constructs a defined gut bacterial community of 104 strains and investigates strain-strain and strain-nutrient interactions through amino acid dropout experiments.

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

The paper identifies cancer-associated fibroblasts in glioblastoma and shows their pro-tumoral effects through interactions with glioblastoma stem cells.

The paper develops a microfluidic system to study T cell interactions with tumor spheroids, showing that collective T cell behaviors, not individual actions, drive tumor regression.

This study investigates how radiation and ONC201 modulate the unfolded protein response (UPR) in prostate cancer cells, enhancing cell death and radiosensitivity.

This paper develops a CRISPR-engineered bacteriophage T4 nanoparticle platform to create multiplex SARS-CoV-2 vaccine candidates, showing potent immune responses and protection in animal models.

This paper uses computational methods to identify key structural features of the SARS-CoV-2 FSE RNA element and proposes mutations to disrupt viral translation.

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

The paper develops a machine learning method to optimize peptide binding to class II MHCs by modifying anchor residues, validated through a yeast display assay.

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

The paper describes synthetic monoclonal antibodies that neutralize SARS-CoV-2 by binding to the spike protein and blocking ACE2 receptor interaction, showing potent antiviral activity.

The paper develops a machine learning method to design peptide vaccines for SARS-CoV-2, achieving high predicted coverage and robustness against epitope drift.

This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.

This study identifies the c-Met/β1 integrin complex as a driver of breast cancer intravasation and bone metastasis, suggesting therapeutic targeting could prevent metastases.

This study shows that deleting P2Y6R in adipocytes improves glucose homeostasis and prevents obesity, while deletion in skeletal muscle impairs glucose uptake.

This study identifies PTEN-deficiency-associated CXC-chemokine signaling as a driver of radiotherapy resistance in prostate cancer and shows that targeting CXCR1/2 improves radiotherapy outcomes.

This paper develops a novel allograft model of high-risk prostate cancer that mimics human disease features and responds to radiotherapy.

This study develops a giant magnetoresistive biosensor to detect protease activity by measuring magnetic nanoparticle release, showing sensitivity to papain in urine.

This study shows that CTCF degradation promotes distal VH-to-DJH joining by enabling cohesin-driven RAG-scanning in pro-B cells.

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

This study identifies PfLPL1 as a lysophospholipase essential for generating neutral lipids required for hemozoin formation in malaria parasites, disrupting parasite growth and development.