W. Wang

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

The paper creates a mutant fitness compendium for Bifidobacterium breve to identify molecular factors affecting colonization and host-microbe interactions.

Proteogenomic characterization reveals antitumor mechanisms of intrahepatic cholangiocarcinoma

This study identifies two NRG-related clusters in iCCA using multi-omics data and develops a prognostic signature model, NPS, which correlates with drug response and immunotherapy outcomes.

The WY domain of an RxLR effector drives interactions with a host target phosphatase to mimic host regulatory proteins and promote Phytophthora infestans infection.

This study characterizes the interaction between the WY domain of the P. infestans effector Pi04314 and the host PP1c phosphatase, showing how it mimics host regulatory proteins to promote infection.

Dietary n-3 PUFA enhances DMI in transition cows by regulating taste transduction gene expression in liver associated with rumen microbial alteration

This study shows that dietary n-3 PUFA improves dry matter intake in transition cows by altering liver gene expression related to taste transduction and modifying rumen microbial composition.

Association between the rifampicin resistance mutations and rifabutin susceptibility in Mycobacterium tuberculosis: a meta-analysis

This study identifies RIF-resistance mutations in M. tuberculosis associated with rifabutin susceptibility through a meta-analysis of 25 studies.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

Transcription factor ScWRKY4 in sugarcane negatively regulates the resistance to pathogen infection through the JA signaling pathway

This study identifies ScWRKY4 as a negative regulator of sugarcane resistance to pathogens via the JA signaling pathway by suppressing JAZ gene expression.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists

The paper introduces SPOTIT and SPOTall sensors to detect GPCR agonist localization in the whole brain using fluorescent integrator sensors for multiple neuromodulators.

The diminished ovarian reserve with chronic stress induced by tripterygium with chronic unpredictable mild stress in SD rats

This study establishes a rat model of diminished ovarian reserve (DOR) combined with chronic unpredictable mild stress (CUMS) and finds that stress exacerbates ovarian dysfunction.

D614G and Omicron SARS-CoV-2 variant spike proteins differ in the effects of N-glycan modifications on spike expression, virus infectivity, and neutralization by some therapeutic antibodies

This study compares how N-glycan modifications affect spike expression, infectivity, and antibody neutralization in SARS-CoV-2 D614G and Omicron variants.

ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

Determinants of Disordered Protein Co-Assembly Into Discrete Condensed Phases

The paper identifies sequence determinants of IDR co-assembly into distinct condensed phases and reveals physicochemical principles governing phase separation specificity.

Membrane and glycocalyx tethering of DNA nanostructures for enhanced uptake

This study enhances DNA nanostructure cellular uptake by targeting membrane and glycocalyx, showing improved uptake and endocytic pathways involving scavenger receptors and clathrin/caveolin mechanisms.

An accessible and generalizable in vitro luminescence assay for detecting GPCR activation

This paper introduces an in vitro luminescence assay, IGNiTR, for detecting GPCR activation with applications in ligand characterization and screening.

Noise-robust, physical microscopic deconvolution algorithm enabled by multi-resolution analysis regularization

This paper introduces noise-robust deconvolution algorithms for fluorescence microscopy using multi-resolution analysis regularization, improving resolution and SNR across various imaging techniques.

A compact regulatory RNA element in mouse Hsp70 mRNA

The paper identifies a compact RNA structure in mouse Hsp70 mRNA that may regulate cap-independent translation during heat shock.

Design, evaluation and implementation of synthetic isopentyldiol pathways in Escherichia coli

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

Synthetic cell armor made of DNA origami

This paper develops a DNA origami nanoshell to protect cells from mechanical stress by enhancing membrane stiffness and reducing lipid fluidity, improving cell viability.

GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

The paper shows that transient EZH2 inhibition with Tazemetostat during T cell expansion maintains stemness and improves adoptive T cell therapy outcomes in a murine model.

Frequency variation and dose modification of benznidazole administration for the treatment of Trypanosoma cruzi infection in mice, dogs and non-human primates

This study evaluates modified benznidazole dosing schedules in mice, dogs, and non-human primates to improve parasitological cure rates for Trypanosoma cruzi infection.

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

This study investigates the role of mouse mammary tumor virus (MMTV) in colitis and dysbiosis in IL-10-/- mice, finding that MMTV contributes to disease severity and that antiretroviral therapy reduces MMTV load and improves symptoms.