W. Zhou

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

PASTE enables efficient, programmable gene integration without DNA breaks, applicable for research, cell engineering, and gene therapy.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows that extrinsic motivators increase children's cooperation in forest conservation games across three countries.

This paper introduces a radially and azimuthally polarized microscope to measure single-molecule orientation and dynamics with high precision, revealing cholesterol-induced changes in membrane behavior.

This study shows that humanized mice with engrafted human immune cells can resist human gut microbes, but microbial communities differ from those in non-humanized mice.

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

The paper uses single-cell CRISPR perturbation to study how transcription factors influence progression speed and trajectory choice in early T-cell development.

This study investigates how excess calories affect lipid droplet structure in adipose tissue, finding that bile acids and tissue-specific factors influence droplet remodeling and adipocyte size.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study modifies the transmembrane helix lengths of TatA and TatB in E. coli to assess the role of hydrophobic mismatch in Tat pathway function, finding that 15 residues are optimal for membrane integrity and transport activity.

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

The paper describes a workflow for cultivating skin, oral, and gut microbes using metagenomic data and validates its effectiveness.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

Cryo-EM and EPR analysis reveal cooperative substrate binding in BmrCD in an architecture primed for transport.

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

This study uses single-cell RNA sequencing to analyze aging-related changes in subcutaneous adipose tissue, revealing shifts in cellular roles and metabolic phenotypes associated with aging.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study examines gene expression evolution in Trinidadian guppies during parallel adaptation, finding both plasticity and divergence in transcriptional responses across populations.

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

This study shows that bile acid overload in a mouse model impairs brown adipose tissue thermogenic function, with mitochondrial dysfunction and senescence gene induction.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

This study develops a new paralog removal pipeline (PPD) for Hyb-Seq data, showing it resolves conflicts with RAD-seq in phylogenomic analyses of Hamamelis and Castanea.

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

The paper introduces DNA-origami-based fluorescence brightness standards for fast and convenient protein counting in live cells, compatible with various imaging applications.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.