X. Guo

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

This paper characterizes bacteriophage JD419, which has a broad host range and retains lytic activity under various conditions, and reports its genome lacking virulence or antibiotic resistance genes.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study identifies a novel mechanism where Src-mediated phosphorylation of Rpt2-Y439 regulates proteasome function at cellular membranes, impacting cancer therapy response.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

The paper presents a pipeline for extracting and analyzing plant traits from field images, showing improved accuracy in plant height measurement compared to manual methods.

The paper identifies BSL protein phosphatase polarization as a spatiotemporal molecular switch governing asymmetric cell division in Arabidopsis stomatal stem cells.

The paper reveals the structure and mechanism of phage-encoded SAM lyases, showing they function as lyases rather than hydrolases, forming MTA and L-homoserine lactone through a unimolecular reaction.

This study shows that deamidated fibronectin with isoDGR motifs promotes vascular fibrosis and atherosclerosis by enhancing integrin signaling and leukocyte recruitment.

The paper identifies a family of bacterial peptidyl arginine deiminases (PADs) responsible for arginine deimination in lasso peptides, leading to citrulline-containing variants.

This study shows IFITM3 inhibits viral fusion by altering membrane curvature and stiffness, with its amphipathic helix playing a key role in these effects.

The paper shows that auxin regulates xyloglucan complexity, which affects cell wall mechanics and differential growth in plant hypocotyls.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

This study investigates glycyrrhizin's effect on LPS-induced inflammation in goat ruminal epithelial cells, finding it reduces inflammatory cytokines and protects cell structure.

The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.

This study isolates multiple SARS-CoV-2-neutralizing antibodies through site-directed screening, showing potent protection against virus infection.

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

The paper re-analyzes soil carbon data from a tropical forest elevation gradient experiment, finding no significant SOC loss under warming, contradicting previous conclusions.

This paper introduces A-Star, a method for detecting rare mutations with high sensitivity and multiplexing capability, achieving detection as low as 0.01% allele frequency.

This study evaluates the binding of ritonavir, lopinavir, and darunavir to SARS-CoV-2 proteases using molecular modeling, finding that ritonavir and lopinavir inhibit CEP_C30 more effectively than darunavir inhibits PLVP.

This study examines how varying levels of dietary NFC/NDF affect rumen microbiomes in Karakul sheep over four periods, finding reduced ruminal pH and bacterial counts with higher NFC/NDF, but no significant changes in dominant bacterial phyla or genera.

The paper compares PAM-flexible Cas9 variants (xCas9 and Cas9-NG) and wild-type Cas9 across gene knock-out, activation, and suppression using a high-throughput screen, finding that PAM flexibility reduces targeting efficiency and that Cas9-NG outperforms xCas9.

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.

This paper identifies a stepwise endonuclease activity in PfAgo that enables multiplex gene detection through a platform called RADAR, applied to distinguish human papillomavirus serotypes.