X. Lin

This paper develops a CRISPR-Cas13-based strategy called PAC-MAN to inhibit SARS-CoV-2 and influenza A virus in human cells, showing it can degrade viral sequences and reduce replication.

This paper introduces RLP/KSeq, a method to rapidly map receptor-like protein (RLP) and receptor-like kinase (RLK) genes in plants, demonstrating its application in identifying PRRs in Solanum species.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

The paper measures dissolved oxygen dynamics in a hydropeaked river system to identify hydrobiogeochemical tipping points driven by rapid hydrologic changes.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

The paper shows that H3K27me3, deposited by PRC2, is involved in cell differentiation in the unicellular diatom Phaeodactylum tricornutum.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

This paper introduces a hydrogel beads platform for single-cell phenotyping and digital molecular detection, demonstrating its utility in analyzing genotype-phenotype correlations.

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

This study uses nanopore sensing to analyze actin dynamics and drug binding in native, unmodified actin molecules, revealing transitional states and binding stoichiometries.

This study investigates how PRC2 interacts with chromatin using single-molecule force spectroscopy and simulations, revealing new binding configurations and their regulation.

This paper presents an HCV vaccine strategy using redesigned E2 cores displayed on nanoparticles to elicit broadly neutralizing B-cell responses.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

This study tracks the development of a potent ZIKV-specific antibody in a convalescent human, revealing limited somatic hypermutation and high germline identity.

This study identifies CO2 tolerance as a virulence trait in Cryptococcus neoformans, linking it to disease severity and antifungal drug susceptibility.

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

The paper uses a biogeochemistry model to project changes in alpine grassland carbon dynamics under climate change and elevated CO2, finding a net carbon sink with decreasing sequestration capacity and precipitation's growing role.

The paper identifies histotype-specific regulatory elements in ovarian cancer by integrating chromatin landscapes and somatic mutations, highlighting the PAX8 pathway's role in tumor development.

The paper maps cancer-risk SNPs to tissue-specific eQTL networks, finding they cluster in functionally related communities and target oncogenes and tumor suppressor genes.

The paper analyzes the activation of elephant shark mineralocorticoid receptor by corticosteroids and progesterone, finding that aldosterone is absent in cartilaginous fishes and progesterone activates shark MR but not human MR.

This study examines transcriptomic changes in the diatom Phaeodactylum tricornutum under elevated pCO2, finding down-regulation of chromatin structure genes and up-regulation of histone acetylation enzymes and transposable elements.

This paper demonstrates that gp41ECTO is the main source of HIV-1 envelope metastability and shows that stabilizing it improves nanoparticle assembly and induces more effective tier 2 neutralizing antibodies.

This study tracks avian influenza virus evolution in wild birds across three migratory flyways in Georgia, revealing subtype diversity, reassortment patterns, and genetic relationships with global AIV populations.

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

This study identifies Alphaproteobacteria as the primary diazotrophs in a Sphagnum peatland, dominated by Mo-based nitrogenase, with activity influenced by light, O2, and CO2.