Y. Wang

This paper describes an in vivo qHTS method using C. elegans to assess drug toxicity and therapeutic potential, demonstrating its feasibility with anti-infective agents and toxicological compounds.

This study establishes a Tetrasphaera-enriched microbiome for enhanced biological phosphorus removal using allylthiourea, achieving high nutrient removal and recovery.

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

The paper develops a single-cell multi-omics platform to simultaneously profile transcriptome and proteome in mouse oocytes, revealing transcriptome-proteome heterogeneity and identifying maturational signatures.

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

The paper identifies shared minor histocompatibility antigens (mHAs) that could enhance graft versus leukemia (GvL) effects while minimizing graft versus host disease (GvHD) in allogeneic hematopoietic cell transplants.

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

The paper evaluates drought and flooding resistance in maize germplasm using multivariate analysis and identifies key physiological indicators for resistance.

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study reveals the pathway and mechanism of TRiC-mediated tubulin folding using cryo-EM structures and XL-MS, showing how tubulin is stabilized during the ATPase cycle.

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study shows that reducing SURF4 in the liver decreases PCSK9 and increases LDLR, leading to lower plasma cholesterol despite reduced lipoprotein secretion.

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

This study identifies Galectin-8 as a functional ligand of LILRB4 that promotes MDSC expansion and tumor growth, suggesting its blockade as a potential immunotherapy strategy.

This study identifies naRNA as a pre-assembled composite DAMP in neutrophils that drives NET formation and inflammation via TLR8/TLR13, redefining NETs as intentional inflammatory agents.

This study identifies CreTPT3 as a critical chloroplast transporter in Chlamydomonas, showing its role in metabolite transport, oxidative stress prevention, and subfunctionalization with CreTPT2.

This study uses cryo-EM to reveal structural details of TRiC/CCT-mediated folding of tubulin and actin with plp2, showing how plp2 coordinates substrate translocation and folding.

This study tracks the metabolic gene expression and spatial organization of engineered human liver tissues after implantation in vivo.

This study investigates how DNA sequence and internucleosomal interactions influence nucleosome array compaction using Atomic Force Microscopy and develops a theoretical model to explain the results.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

The paper investigates how manganese inhibits COQ7 activity and how cobalt can counteract this inhibition by metal exchange at the di-iron active site.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.