Y. Yang

Robust Small Molecule-Aided Cardiac Reprogramming Systems Selective to Cardiac Fibroblasts

This study identifies a chemical combination that enhances cardiac reprogramming of fibroblasts into cardiomyocytes with improved selectivity and efficiency.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and Alleviates Chondrocyte Osteoarthritis Mediated by Exosomal ANXA1

This study shows that PPARγ enhances exosome biogenesis in fibroblast-like synoviocytes via the ESCRT pathway, and these exosomes containing ANXA1 alleviate osteoarthritis by inhibiting ERK phosphorylation and chondrocyte apoptosis.

Refining the taxonomy of the order Hyphomicrobiales (Rhizobiales) based on whole genome comparisons of over 130 genus type strains

This paper proposes a genome-based framework to refine the taxonomy of the Hyphomicrobiales order by reassigning genera to families based on core-genome phylogenies and amino acid identity thresholds.

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology

This study shows that Sendai virus persists in lung innate immune cells, leading to chronic lung disease by upregulating antiviral and inflammatory genes.

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

This study identifies and evaluates LFS-1107, a CRM1 inhibitor that suppresses ENKTL cell growth by blocking NF-κB signaling and shows promise for clinical translation.

Endothelial Cell Serum and Glucocorticoid Regulated Kinase 1 (SGK1) Mediates Vascular Stiffening

This study investigates the role of endothelial cell SGK1 in vascular stiffening, finding that its inhibition reduces stiffness in both mouse models and human endothelial cells.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Fabrication of Crescent Shaped Microparticles for Particle Templated Droplet Formation

This paper fabricates crescent-shaped hydrogel microparticles that template uniform aqueous droplets and demonstrate pH-responsive fluorescence and compartmentalization.

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

Keywords to success: a practical guide to maximise the visibility and impact of academic papers

The paper provides evidence-based recommendations to improve the discoverability and impact of academic papers through optimized use of keywords and abstract structure.

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

The paper presents cryo-EM structures of human SIDT1 and SIDT2, revealing their dimeric architecture and demonstrating low-pH-dependent RNA binding and oligomerization.

ER mediates spatial regulation of lysosome-endosome interactions via motion switch at junction sites

The paper investigates how lysosomes and endosomes interact with the ER through spatial regulation, revealing a mechanism involving actin cytoskeleton condensation and the VAP-STARD3-YWHAH pathway.

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated Protein Kinase C regulation

This paper shows Pin1 regulates PKC through a non-catalytic mechanism by binding its C-terminal tail via a novel bivalent interaction mode.

Electrochemically controlled blinking of fluorophores to enable quantitative stochastic optical reconstruction microscopy (STORM) imaging

This paper introduces EC-STORM, an electrochemical method to control fluorophore blinking for STORM imaging, improving molecular counting and imaging quality over conventional photochemical STORM.

Characterization of sinking and suspended microeukaryotic communities in spring Oyashio waters

This study characterizes sinking and suspended microeukaryotic communities in Oyashio waters using 18S rDNA metabarcoding, revealing depth-related differences and functional roles in the biological carbon pump.

Inducer of CBF Expression 1 (ICE1) Promotes Cold-enhanced Immunity by Directly Activating Salicylic Acid Signaling

The paper identifies ICE1 as a key regulator linking cold stress and SA signaling to enhance plant immunity against pathogens.

miRNA and mRNA Signatures in Human Acute Kidney Injury Tissue

This study identifies miRNA and mRNA signatures in human AKI tissue, revealing their roles in inflammation, immune activation, and epithelial-to-mesenchymal transition, and highlights the importance of using appropriate reference controls.

Sensitivity of BA.2.86 to prevailing neutralising antibody responses

This study assesses BA.2.86's sensitivity to neutralising antibodies using monoclonal antibodies and serum samples from Stockholm.

Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation

This study identifies a mechanism where cytoskeletal activation of NHE1 drives secondary volume increase and affects cell proliferation in response to hypotonic stress.

Plant immunity activated and suppressed by a conserved effector protein family in mirid bug Riptortus pedestris

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

Multitask Learning of Longitudinal Circulating Biomarkers and Clinical Outcomes: Identification of Optimal Machine-Learning and Deep-Learning Models

This study evaluates machine learning and deep learning models for predicting clinical outcomes using high-dimensional longitudinal biomarker data from a lung cancer trial, finding that MFPCA-Cox outperforms other methods.

The diversity and ecological significance of microbial traits potentially involved in B12 biosynthesis in the global ocean

This study examines microbial traits involved in B12 biosynthesis in the global ocean, revealing that environmental factors select functional traits over taxonomy and that functional redundancy drives community assembly.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

Anti-PD-1-iRGD Peptide Conjugate Boosts Antitumor Efficacy via Engagement Augmentation and Penetration Enhancement of T cells

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

Functional dissection of KATP channel structures reveals the importance of a conserved interface

This study identifies a conserved interface in KATP channels critical for Mg-ADP activation through mutagenesis experiments and structural analysis.

Correlative single-cell hard X-ray tomography and X-ray fluorescence imaging

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.