Y. Zhang

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This paper identifies BysR as a LysR-type regulator that activates ambR1 to control occidiofungin production in Burkholderia sp. JP2-270 and reveals its broader regulatory role in metabolism and motility.

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

This study shows that overexpressing mitochondrial-targeted glutamine synthetase in tomato leaves increases assimilate export, leading to earlier flowering and higher yield.

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

This paper investigates the distinct roles of Nrf1 and Nrf2 in the reductive stress response to DTT, showing differential regulation of redox and ER stress defense genes.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

The paper identifies a genetic locus associated with root bending in response to salinity, showing that extensin arabinosylation is required for directional root responses to salt.

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

The paper examines how changes in generation time affect human mutation spectra, finding that such changes cannot fully explain observed mutation patterns, suggesting other factors are involved.

This paper introduces a new eccDNA purification method and a full-length sequencing approach to improve eccDNA analysis and mapping.

The paper constructs a promoter-GFP fusion reporter library to study the systemic expression patterns of 41 c-di-GMP metabolism-related genes in Pseudomonas aeruginosa under various growth conditions.

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

This study shows HDAC3 is essential for pDC development and hematopoietic progenitor homeostasis, with HDAC3 repressing cDC1-associated genes to promote pDC differentiation.

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

The paper shows that shade-induced transcription of PIF-Direct-Target Genes occurs before H3K4me3 chromatin modification increases, suggesting H3K4me3 may buffer rather than cause shade-induced gene expression.

The paper develops adenine base editors in Arabidopsis thaliana that can induce inheritable A-to-G mutations in non-canonical PAM contexts with high efficiency.

This study demonstrates survival intravascular photoacoustic imaging of lipid-rich atherosclerotic plaques in a rabbit model using MRI-guided IVPA catheter, validated by histology.

The paper isolates rare memory B cells from vaccinated individuals to generate anti-poxvirus monoclonal antibodies, identifying one with high efficacy against viral infection.

The paper identifies novel NHP metabolites in Arabidopsis and shows that their methyl ester form can rescue a biosynthesis mutant's disease susceptibility.

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

The paper identifies mesothelial cell-derived antigen-presenting CAFs in pancreatic cancer that induce regulatory T cells through antigen-specific interactions.

This study investigates the role of human LAMP1 in LASV fusion, showing it accelerates pore formation but only modestly increases infection, with enhanced pore dilation when fusion is forced at the plasma membrane.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

The paper develops a red-shifted NanoLuc variant (QLuc) and uses it for in vivo immunobioluminescence imaging to improve deep-tissue visualization in mice.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

This study identifies self-organized canals in bacterial colonies that enable long-range directed transport of cells and vesicles, driven by biosurfactant-mediated fluid flows.