Y. Zhang

This study identifies a mechanical circuit in End4p that regulates force transmission during clathrin-mediated endocytosis in fission yeast.

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

This study develops a high-throughput plasma proteome analysis workflow using UV-assisted digestion, 5-plex labeling, and MS-based high abundance protein removal to improve quantification of low-abundance proteins.

This study shows Prdm1 regulates liver cNK cells and ILC1s, affecting cancer metastasis and immune communication, with implications for liver cancer immunotherapy.

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

This paper introduces AGMs for long-term in vivo molecular monitoring, demonstrating detection of dopamine and serotonin in blood and in vivo dopamine release in mice for over a week.

This paper conducts a bibliometric and temporal trend analysis of Nipah virus research, revealing increased publication rates and highlighting gaps in drug and vaccine development.

The paper identifies a cyclopropene-quinone pair that significantly enhances reactivity and demonstrates two activation mechanisms for bioorthogonal imaging.

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

This study shows that DON inhibits PDAC growth by targeting asparagine metabolism, and combining DON with ASNase reduces metastasis.

The paper develops a CRISPR/Cas9 system for Arabidopsis using the NUC1 promoter, achieving high editing efficiency and stable inheritance in the T2 generation.

This study shows that warming reduces fungal abundance and shifts fungal community composition in semi-arid grasslands, leading to reduced soil carbon efflux.

This study identifies 22 RNA viruses in Laodelphax striatellus, including 17 novel ones, and shows their adaptability across related planthopper species.

The paper identifies an entropic charge separation mechanism that limits coarsening in nanoscale condensates, explaining their long-term stability.

This study identifies mitoBKCa, a BKCa splice variant in mitochondria of breast cancer cells, showing it modulates energy production and promotes proliferation, suggesting it as a potential therapeutic target.

This study identifies Akkermansia muciniphila as a key strain in fecal microbiota transplantation that alleviates gut barrier injury by modulating the Wnt/β-catenin signaling pathway in an ETEC infection model.

This study identifies distinct Tfh cell populations during chronic and acute helminth infections and shows their role in type 2 immune responses.

This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.

This study develops a method to express, purify, and insert SARS-CoV-2 M protein into lipid bilayers, characterizing its structural properties using AFM and Cryo-EM.

The paper examines gene expression and lipid changes in three panicoid grasses under chilling stress, revealing conserved and species-specific responses and identifying potential target genes for improving chilling tolerance.

HyperPRI provides a dataset of hyperspectral and RGB images of underground plant roots for non-destructive analysis, showing that combining spectral and spatial data improves segmentation.

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

The paper identifies a widespread bacterial symbiont, Enterococcus casseliflavus, in the invasive pest Spodoptera frugiperda that mediates insecticide detoxification and suggests its potential for insecticide resistance management.

This paper introduces Graph-Dynamo, a framework that learns stochastic cellular state transition dynamics from single cell data using graph-based methods and Fokker-Planck equations.

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

The paper investigates how lysosomes and endosomes interact with the ER through spatial regulation, revealing a mechanism involving actin cytoskeleton condensation and the VAP-STARD3-YWHAH pathway.

This study identifies psbD BLRP as a target RNA of GUN1, an RNA-binding protein essential for early PSII biogenesis during seedling development.

This paper identifies how PNUTS interacts with PP1-8e through specific motifs and polymorphisms to form the PJW/PP1 complex, regulating Pol II transcription in Leishmania.

This study shows that enhanced ISGylation reduces respiratory distress in Francisella novicida infection by modulating SAMHD1 function, suggesting USP18 inhibition as a therapeutic strategy.