Y. Zhang

This study shows FDX1 is essential for embryonic development and lipid homeostasis, with knockout mice showing embryonic lethality and lipid droplet accumulation.

This paper introduces a hybrid resolution protein model (HyRes) to accurately simulate the coupling between protein secondary structure and liquid-liquid phase separation in intrinsically disordered proteins.

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

This study shows that prebiotic proanthocyanidins inhibit reflux-induced esophageal adenocarcinoma by altering gut microbiome and esophageal metabolome, reducing inflammation and cellular damage.

The paper identifies PPARalpha activation as protective against myocardial ischemia-reperfusion injury by maintaining cardiac metabolic homeostasis, using multi-omics data from rat hearts.

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

This study identifies Tafazzin's role in tamoxifen resistance by regulating phospholipid composition in ER+ breast cancer cells, showing that TAZ depletion promotes resistance via an LPC-LPA axis.

This study shows that WASP regulates nucleolar structure and function, affecting rRNA transcription and inflammatory cytokine response in macrophages.

This study uses phylogenomic analyses with extensive taxon sampling to propose a new infrageneric classification of Pourthiaea, finding cytonuclear discordance and hybridization as key factors.

The paper shows that XBAT35.2 modulates FLS2 stability by ubiquitinating ESCRT-I subunits VPS37-1 and VPS28-2 with distinct ubiquitin chains, enhancing plant immunity.

This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.

This paper develops SHRIMP, a genetically encoded red fluorescent hydrogen peroxide sensor with high brightness and minimal photoactivation, validated in mammalian cells and primary islet tissue.

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

This study defines the DNA binding and cleavage mechanisms of Type I-C CRISPR-Cas3 using cryo-EM and identifies anti-CRISPR proteins that inhibit its activity in human cells.

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

This paper introduces a method to enable multicolor live-cell STED imaging with at least 4 colors using phasor analysis to separate dyes of the same spectrum.

This study identifies essential genes and genomic features of Xanthomonas citri using transposon mutagenesis, revealing insights into its genome organization and potential therapeutic targets.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This study shows ADAR2 inhibits ER-targeted mRNA translation by regulating SRP assembly in the nucleolus without requiring RNA binding or A-to-I editing.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This study simulates the feeding and respiration of early Cambrian cnidarian polyps using CFD to show how muscle contractions drive water flow, supporting hypotheses about ancestral medusozoan behavior.

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

This study shows H2A.Z regulates plant salt response by modulating gene transcription, with its occupancy affecting gene expression levels under salt stress.

This study shows that dietary n-3 PUFA improves dry matter intake in transition cows by altering liver gene expression related to taste transduction and modifying rumen microbial composition.

The paper identifies collateral synthetic lethality between HDAC1 and HDAC2 in cancer cells and shows that targeting HDAC2 can suppress tumor growth by disrupting the NuRD complex.

This study evaluates the synergistic effect of tigecycline with apramycin and amikacin against tet(X)-harboring Acinetobacter spp., finding significant synergy with apramycin.

This study determines the structures of RNA primer/template complexes with adenosine and guanosine ligands, revealing structural reasons for slow RNA primer extension with adenosine substrates.