Y. Zhu

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study identifies SMARCAD1 as a critical factor for replication fork stability, showing its role in preventing genome instability and enhancing resistance to replication poisons.

This study uses proteomics to identify down-regulated ECM proteins in guinea pig cochleae after noise exposure, linking them to hearing loss mechanisms.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

This study shows that Pseudomonas aeruginosa secretion causes acute emphysema in mice, which requires immune suppression and recapitulates human COPD features.

The paper proposes a model combining UVA and UVB inactivation for SARS-CoV-2, showing UVA contributes to sunlight inactivation and suggesting updated models should include UVA effects.

This study identifies Snord67 as a regulator of lymph node metastasis in breast cancer by modulating U6-mediated alternative splicing.

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

This study identifies Rac1/ROCK-driven membrane dynamics as a mechanism promoting necroptosis in NK cell cytotoxicity, enhancing target selectivity in cancer.

This study investigates how the marine ciliate Mesodinium rubrum controls sequestered cryptophyte organelles, finding limited transcriptional control and significant gene expression from the prey.

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

This study evaluates the in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris isolates from a New York outbreak, showing it is significantly more active than existing antifungals.

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This paper demonstrates a tunable ultrafast stroboscopic TEM system that reduces radiation damage in macromolecules by increasing critical dose at room temperature.

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study shows that NRT1.1 in Arabidopsis roots coordinates with K+ channels to regulate uptake and allocation of potassium.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

The paper develops CAR-expressing iPSC-derived macrophage cells with antigen-dependent anti-cancer functions effective against both liquid and solid tumors.

The paper develops non-toxic virucidal macromolecules effective against multiple influenza strains in vitro and in vivo.