Y. Zhu

This study identifies LEAFY as a pioneer transcription factor in plants that licenses cell reprogramming to floral fate by displacing histones and recruiting chromatin remodelers.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

This paper develops a combined abdominal heart and aorta transplant model in mice to study allograft vasculopathy and immunosuppressive strategies.

This study compares transcriptional responses to oncogenes in cancer-resistant and -prone species, finding that naked mole rat cells resist Ras-induced changes due to dampened PI3K/AKT signaling.

The paper shows TFL1 and FT antagonistically regulate floral fate through chromatin recruitment and competition, with LFY as a key target gene.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study analyzes HTNV genetic diversity and evolution in China and neighboring regions, identifying phylogroups, recombination events, and geographic clustering patterns.

This study identifies PI4KII as essential for phagosomal TLR4 signaling and MHC-II presentation in dendritic cells by facilitating TIRAP recruitment.

The paper investigates the origin and evolution of A-to-I RNA editing in metazoans, finding it emerged in the common ancestor and is nonadaptive in most regions except for specific taxa.

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

This study integrates radiomic and genomic data from HNSCC patients to find associations between imaging features and genomic biomarkers, achieving moderate predictive accuracy for HPV and TP53 mutation status.

This paper introduces a hydrogel beads platform for single-cell phenotyping and digital molecular detection, demonstrating its utility in analyzing genotype-phenotype correlations.

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.

This study uses whole-genome sequencing to identify four distinct genotypes in metastatic castration-resistant prostate cancers, with potential clinical implications for patient stratification.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

The paper uses single-cell proteomics to show TMSB4X downregulation drives actin release for stereocilia assembly in hair cells.

This paper develops an automated real-time PCR assay for rapid detection of Candida auris using the BD MAX system, achieving high sensitivity and specificity in clinical samples.

The paper examines 3D chromatin changes in T-ALL, identifies TAD fusion events linked to oncogene activation, and shows drug treatments can restore some interactions.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

This study optimizes antimicrobial peptides to enhance their activity and specificity against E. coli by modifying structure and introducing a phage-displayed targeting moiety.

This paper describes a resource of pediatric high grade glioma (pHGG) data and biospecimens from the CBTTC and PBTA, including genomic, clinical, and imaging data, along with cell lines and tissue microarrays.

This study shows arsenite exposure reduces p300 and H3K27ac at enhancers in MEF cells, affecting gene expression and potentially contributing to arsenic-related disease.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.