Z. Chen

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This paper introduces OrgaTracker, a system using deep learning to track and analyze organoid growth, and generates artificial organoids from sketches.

This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study presents the cryo-EM structure of a gabapentin-bound calcium channel, revealing the binding pocket and explaining isoform selectivity.

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

This study evaluates how musculotendon parameter derivation affects muscle force estimation in lower limb models, identifying key simplifications and sensitivity to parameter errors.

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

This paper develops stretchable, transparent microelectrode arrays using gold-coated silver nanowires, demonstrating high optical transparency, low impedance, and stable performance for biomedical applications.

This study identifies and characterizes the N-terminal domain of the Atlantic sea lamprey corticoid receptor, showing its critical role in steroid-mediated transcriptional activation and promoter-specific regulation.

This study identifies YTHDF1 as an oncogenic m6A reader promoting AML by enhancing oncogenic translation and shows tegaserod inhibits its function.

The paper presents cryo-EM structures of CaV1.2 channels with auxiliary subunits and chaperones, revealing assembly mechanisms and drug binding sites.

This paper develops human spinal microphysiological systems to model opioid-induced tolerance and hyperalgesia, showing altered neural activity and receptor downregulation with prolonged opioid exposure.

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

The paper identifies novel sperm proteins in mammals using cryo-electron tomography and AlphaFold2 models, revealing their structural roles in flagellar mechanics.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

This study reports cryo-EM structures of RuvB in complex with DNA and nucleotides, revealing the mechanism of Holliday junction branch migration and the ATP hydrolysis cycle in RuvB.

The paper introduces a new maize transformation system using BABY BOOM and GRF-GIF factors that significantly improves transformation efficiency.

This study shows that lysosomal cystine export via CTNS regulates mTORC1 signaling, influencing kidney epithelial cell fate and function in cystinosis.

This study shows that hepaCAM suppresses GBM stem cell invasion by balancing ECM adhesion and signaling pathways, suggesting it as a potential therapeutic target.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

The paper links collective migration to differentiation in hPSC-derived hepatocytes, showing a significant increase in maturation through a deep-learning gene circuit.

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

This paper shows that eliminating monocyte chemoattraction increases neutrophil infiltration in glioblastoma, promoting tumor aggression, and that targeting both monocytes and neutrophils improves survival in mouse models.

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.