Z. Chen

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

The paper examines how human disturbance affects spatiotemporal associations among mountain forest terrestrial mammals using camera-trap data from the eastern Himalaya.

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

Rof is a key regulator of Rho and transcription termination in bacteria

This study reports the cryo-EM structure of the Rho-Rof antitermination complex and shows Rof inhibits Rho-dependent termination, essential for bacterial virulence.

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

Gut microbes contribute to variation in foraging intensity in the honey bee, Apis mellifera.

The paper shows gut microbes influence foraging behavior in honey bees by altering microbiome composition and causing changes in foraging intensity through specific microbial inoculations.

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Endocytosis gated by emergent properties of membrane-clathrin interactions

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

Quercetin Suppresses TNBC Cell by Targeting ORM2

This study shows that quercetin inhibits TNBC cell viability by targeting ORM2, with higher ORM2 expression in TNBC cells and reduced viability after ORM2 knockdown.

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

An energy-saving glasshouse film reduces seasonal, and cultivar dependent Capsicum yield due to light limited photosynthesis

This study shows that an energy-saving glasshouse film reduces Capsicum yield by limiting photosynthesis, with greater effects during descending photoperiods.

Exogenous Recombinant N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B; ARSB) Inhibits Progression of B16F10 Cutaneous Melanomas and Modulates Cell Signaling

This study shows that exogenous ARSB treatment reduces B16F10 melanoma tumor size and improves survival by altering chondroitin sulfate levels and modulating cell signaling pathways.

Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7

This study shows ZIP7 enhances ERAD by supplying cytosolic Zn2+ for Rpn11 deubiquitination, rescuing vision loss in Drosophila with misfolded rhodopsin.

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Nano-silver and forskolin regulate rice seed germination mediated by OsPIP2-1 and α-amylase

This study shows nano-silver inhibits and forskolin promotes rice seed germination through regulation of OsPIP2-1 and α-amylase.

In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

The paper establishes an in vitro model of CD8 T cell exhaustion and uses CRISPR screening to identify BHLHE40 as a regulator of T cell exhaustion differentiation.

Defining the mechanisms of action and resistance to the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain models

This study investigates the mechanisms of action and resistance of anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma models, finding differential effects on CD4+ T cell polarization and CD8+ T cell function.

Metal-driven anaerobic oxidation of methane as an important methane sink in methanic cold seep sediments

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions

The paper uses live-cell single-molecule tracking to study how H3K9me affects HP1 protein interactions in fission yeast.

RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism

This study identifies RNA sensing and innate immunity in host embryos as a barrier to interspecies chimerism and shows that modifying host embryos can enhance human cell survival in chimeric embryos.

Cyclic di-GMP interact with putrescine via a PilZ domain receptor YcgR

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

Single-cell analysis of CX3CR1+ cells reveal a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins

The paper identifies BIRC5+ myeloid cells as pathogenic during S. aureus infection using scRNA-seq and genetic fate mapping.

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.