Z. Li

This study uses liver electrical impedance tomography to detect fatty infiltration in obese individuals, finding a negative correlation between EIT conductivity and MRI-measured fat fraction.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This study investigates N-glycosylation sites and glycan-binding ability of SARS-CoV-2 S-protein through phylogenetic analysis, structural comparison, docking analysis, and molecular dynamics simulation.

This study shows that the Toll pathway effector BaraA protects Drosophila from toxins of Gram-positive bacteria and fungi without directly attacking the pathogens.

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This study investigates how white adipocytes adapt to cooler temperatures, finding changes in gene expression, lipid metabolism, and energy source utilization.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study presents a membrane-permeabilized ghost system for Haloferax volcanii to investigate archaellum motility, revealing ATP selectivity, negative cooperativity, and a torque-speed curve with characteristics of both bacterial flagellar motors and F1-ATPase.

This paper identifies ARID1A-deficient cancer cells as vulnerable to pyrimidine synthesis blockade and shows synergy between teriflunomide and AZD6738 in suppressing ARID1A-mutant tumors.

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

The paper shows that S and HE proteins co-evolve to balance attachment and release in coronaviruses, with functional interdependence observed in OC43 and HKU1.

This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

The paper introduces a method to quantify single and multicellular traction forces and matrix remodeling in 3D using a microfabricated sensor, showing increased tissue stiffness in cancer co-cultures.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study examines how ethanol intoxication affects blood-based biomarkers of cerebral injury in mice after traumatic brain injury, finding differential impacts on NSE and NFL levels.

This paper develops a prediction tool for atherosclerotic plaque progression using patient-specific multi-physical modeling and microenvironmental indicators to differentiate stable from unstable plaques.

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

The paper develops an assay using Doppler spectroscopy to predict chemotherapy response in ovarian cancer by analyzing intracellular motion in tumor tissues.

The paper quantifies bacterial strain engraftment after FMT for rCDI and shows long-term stability in non-relapsing recipients, linking strain presence to clinical outcomes.

The paper analyzes viral diversity in deep sea cold seep sediments, finding high endemism and links to microbial hosts and biogeochemical cycling.