Z. Wu

The paper shows that siderophore-mediated iron partition enables stable coexistence between cheaters and partial cooperators in microbial communities.

This study identifies FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer, showing it induces cell cycle arrest, apoptosis, and synthetic lethality through chromatin accessibility reduction and DNA repair impairment.

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

This study shows oleic acid enhances ERAD via lipid droplets to increase SKN-1A levels, reducing steatosis and promoting longevity in C. elegans.

This study identifies c-Jun and JunB binding sites in ALK+ ALCL cells, revealing novel targets and a role for FAM129B in NPM-ALK signaling.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

The paper identifies a new endolysosome process, LEA, where autophagosomes are engulfed by extending arms (LF) without fusion, and describes the molecular markers of engulfed autophagosomes.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

The paper uses cryo-EM to reveal cooperative conformational changes in KaiC hexamers that enable switch-like phosphorylation responses.

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

This study develops a human brain organoid microphysiological platform to model immune-driven brain aging by perfusing aged monocytes and observing their effects on organoid tissues.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

The paper quantifies Prochlorococcus carbon acquisition, showing mixotrophy supports its ecological success in oceanic environments.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

This study shows that reducing dermal white adipose tissue (dWAT) worsens EGFR inhibitor-induced skin rash in mice, and activating PPARγ with rosiglitazone improves skin function without affecting antitumor effects.

This study shows that EBV LMP1 activates mTORC1 and mTORC2 to promote cancer stem cell properties in nasopharyngeal carcinoma, with distinct roles in drug resistance, tumor initiation, and metastasis.

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

This study reveals the dynamic regulation of USP14 and proteasome through cryo-EM structures and time-resolved analysis, identifying three regulatory checkpoints in proteasome function.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

This paper introduces a Bayesian framework to improve the estimation of size-structured matrix population models for microbial dynamics, demonstrating better performance and biological interpretability.

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

The paper shows that VPS13C deficiency leads to lysosomal lipid changes and activates the cGAS/STING pathway via mtDNA accumulation and impaired STING degradation.

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

This study shows TIR signaling enhances the interaction between EDS1/PAD4 and ADR1-L1 and promotes ADR1-L1 oligomerization, crucial for immune activation and cell death.

The paper shows that soil iron levels determine whether maize benzoxazinoids promote or suppress fall armyworm growth.